Department of Occupational and Environmental Medicine, School of Public Health, Wuhan University of Science and Technology, Wuhan 430065, China.
Center of Scientific Research and Experiment, Nanyang Medical College, Nanyang 473006, China.
Asian J Androl. 2022 May-Jun;24(3):238-242. doi: 10.4103/aja202179.
Cilium, an organelle with a unique proteome and organization, protruding from the cell surface, generally serves as a force generator and signaling compartment. During ciliogenesis, ciliary proteins are synthesized in cytoplasm and transported into cilia by intraflagellar transport (IFT) particles, where the inner counterparts undergo reverse trafficking. The homeostasis of IFT plays a key role in cilial structure assembly and signaling transduction. Much progress has been made on the mechanisms and functions of IFT; however, recent studies have revealed the involvement of IFT particle subunits in organogenesis and spermatogenesis. In this review, we discuss new concepts concerning the molecular functions of IFT protein IFT25 and how its interactions with other IFT particle subunits are involved in mammalian development and fertility.
纤毛，一种从细胞表面突出的具有独特蛋白质组和组织的细胞器，通常充当力发生器和信号隔室。在纤毛发生过程中，纤毛蛋白在细胞质中合成，并通过鞭毛内运输（IFT）颗粒运输到纤毛中，其中内对应物经历反向运输。IFT 的动态平衡在纤毛结构组装和信号转导中起着关键作用。IFT 的机制和功能已经取得了很大进展；然而，最近的研究表明 IFT 颗粒亚基参与了器官发生和精子发生。在这篇综述中，我们讨论了 IFT 蛋白 IFT25 的分子功能的新概念，以及它与其他 IFT 颗粒亚基的相互作用如何参与哺乳动物的发育和生育能力。
