Gothi Dipti, Anand Shweta, Patro Mahismita, Vaidya Sameer, Deshmukh Ishani
Department of Pulmonary Medicine, ESI-PGIMSR, New Delhi, India.
Lung India. 2021 Nov-Dec;38(6):552-557. doi: 10.4103/lungindia.lungindia_95_21.
The objective is (1) To evaluate the change in forced expiratory volume in one second (FEV), forced vital capacity (FVC), dyspnea grading, body mass index, and oxygen saturation (SpO) in adults with postinfectious obliterative bronchiolitis (PIOB) over a period of time (2) To evaluate the same parameters in chronic obstructive pulmonary disease (COPD) patients and compare with PIOB.
It was a retrospective observational study involving appropriately managed patients of PIOB and COPD with minimum 3 years of follow-up. Out of a total of 106 patients who followed up from January 2019 to December 2019 and had a follow-up data of more than 3 years, 61 (31 COPD and 30 PIOB) patients were included in the final analysis after applying the inclusion and exclusion criteria.
The baseline FEV and FVC was significantly worse in PIOB group compared to COPD group. In PIOB group, there was nonsignificant increment in both the parameters (FVC by 18.79 ml and FEV by 12.2 ml per year). There was a significant decline in FVC and FEV1 in the COPD group by 106.8 ml and 63.25 ml per year, respectively. There was a significant difference between PIOB and COPD for the yearly change in FVC and FEV (P value being 0.000083 and 0.000033, respectively). In PIOB group, there was increment in modified Medical Research Council (mMRC) score and nonsignificant change in SpO2 whereas the SpO2 and mMRC score had a yearly decline in the COPD group.
The PIOB is characterized by a nonsignificant increase in lung function whereas COPD shows a significant progressive decline.
（1）评估感染后闭塞性细支气管炎（PIOB）成人患者在一段时间内一秒用力呼气容积（FEV）、用力肺活量（FVC）、呼吸困难分级、体重指数和血氧饱和度（SpO）的变化；（2）评估慢性阻塞性肺疾病（COPD）患者的相同参数并与PIOB患者进行比较。
这是一项回顾性观察研究，纳入了管理得当且随访至少3年的PIOB和COPD患者。在2019年1月至2019年12月进行随访且有超过3年随访数据的总共106例患者中，应用纳入和排除标准后，61例（31例COPD和30例PIOB）患者纳入最终分析。
与COPD组相比，PIOB组的基线FEV和FVC明显更差。在PIOB组中，这两个参数均有不显著的增加（FVC每年增加18.79 ml，FEV每年增加12.2 ml）。COPD组的FVC和FEV1分别每年显著下降106.8 ml和63.25 ml。PIOB和COPD在FVC和FEV的年变化方面存在显著差异（P值分别为0.000083和0.000033）。在PIOB组中，改良医学研究委员会（mMRC）评分增加，SpO2无显著变化，而COPD组的SpO2和mMRC评分每年下降。
PIOB的特征是肺功能无显著增加，而COPD则表现出显著的进行性下降。
