Department of Neurosurgery, Dr. D.Y. Patil Medical College and Hospital, Pune, Maharashtra, India.
Department of Ophthalmology and Neurosurgery, Dr. D.Y. Patil Medical College and Hospital, Pune, Maharashtra, India.
Neurol India. 2021 Sep-Oct;69(5):1414-1420. doi: 10.4103/0028-3886.329622.
Primary pituitary tuberculosis (PTA) is a very rare disease. The clinical diagnosis is difficult as it is clinically radiologically indistinguishable from other sellar lesions. We present a case of PTA without any predisposing etiology and radiologically mimicking a pituitary macroadenoma. The patient underwent endoscopic transsphenoidal resection where pus admixed with mucoid was seen coming out of the lesion intraoperatively. Histology of the cyst wall was suspective of tuberculous etiology and QuantiFERON Tb Gold done for confirmation was positive. Postoperatively patient showed obvious improvement in visual symptoms. Patient developed diabetes insipidus and was put on desmopressin and was started with anti-tuberculosis medication for 18 months. Timely surgical intervention followed by anti-tubercular therapy and hormone replacement is the mainstay of treatment in these cases. For intraoperative management, we advise thorough wash with antibiotic and saline rather than curetting the walls of the abscess to decrease the postoperative incidence of endocrine abnormalities.
原发性垂体结核(PTA)是一种非常罕见的疾病。由于其在临床上与其他鞍区病变在影像学上无法区分,因此临床诊断较为困难。我们报告了一例无任何潜在病因且影像学上类似于垂体大腺瘤的 PTA 病例。该患者接受了经鼻内镜蝶窦切除术,术中可见脓液与粘蛋白混合从病变中流出。囊壁的组织学检查提示结核病因,为确认进行了 QuantiFERON Tb Gold 检测,结果为阳性。术后患者的视力症状明显改善。患者出现尿崩症,给予去氨加压素,并开始接受 18 个月的抗结核药物治疗。在这些病例中,及时的手术干预、抗结核治疗和激素替代是治疗的主要方法。对于术中管理,我们建议用抗生素和生理盐水彻底冲洗,而不是刮除脓肿壁,以降低术后内分泌异常的发生率。