Department of General Surgery, Xiangya Hospital Central South University, Changsha 410008, Hunan, P.R. China.
National Clinical Research Center for Geriatric Disorders, Changsha 410008, Hunan, P.R. China.
Biomater Sci. 2021 Nov 23;9(23):7799-7810. doi: 10.1039/d1bm01256h.
Nerve injury is a common complication of surgery. Accidental nerve damage or transection can lead to severe clinical symptoms including pain, numbness, paralysis and even expiratory dyspnoea. In recent years, with the rise of the field of fluorescence-guided surgery, researchers have discovered that nerve-specific fluorescent agents can serve as nerve markers in animals and can be used to guide surgical procedures and reduce the incidence of intraoperative nerve damage. Currently, researchers have begun to focus on biochemistry, materials chemistry and other fields to produce more neuro-specific fluorescent agents with physiological relevance and they are expected to have clinical applications. This review discusses the agents with potential to be used in fluorescence-guided nerve imaging during surgery.
神经损伤是手术的常见并发症。意外的神经损伤或横断可导致严重的临床症状，包括疼痛、麻木、瘫痪，甚至呼气困难。近年来，随着荧光引导手术领域的兴起，研究人员发现神经特异性荧光剂可用作动物的神经标记物，可用于指导手术过程，降低术中神经损伤的发生率。目前，研究人员已经开始关注生物化学、材料化学等领域，以生产更多具有生理相关性的神经特异性荧光剂，预计它们将具有临床应用前景。本文综述了在手术中用于荧光引导神经成像的潜在试剂。
