Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112236. doi: 10.1002/anie.202112236. Epub 2021 Nov 25.
Cancer has emerged over the last decades as one of the deadliest diseases in the world. Among the most commonly used techniques (i.e. surgery, immunotherapy, radiotherapy or chemotherapy), increasing attention has been devoted towards photodynamic therapy. However, the vast majority of clinically applied photosensitizers are not ideal and associated with several limitations including poor aqueous solubility, poor photostability and slow clearance from the body, causing photosensitivity. In an effort to overcome these drawbacks, much attention has been devoted towards the incorporation of a metal ion. Herein, the clinical development of metal-containing compounds including Purlytin , Lutrin /Antrin , Photosens , TOOKAD soluble or TLD-1433 is critically reviewed.
在过去几十年中，癌症已成为世界上最致命的疾病之一。在最常用的技术（即手术、免疫疗法、放射疗法或化学疗法）中，人们越来越关注光动力疗法。然而，绝大多数临床应用的光敏剂并不理想，存在多种局限性，包括水溶性差、光稳定性差和清除速度慢，从而导致光敏性。为了克服这些缺点，人们非常关注金属离子的掺入。在此，对包含 Purlytin、Lutrin/ Antrin、Photosens、TOOKAD 可溶性或 TLD-1433 的含金属化合物的临床发展进行了批判性回顾。
