Department of Biology, Faculty of Nano and BioScience and Technology, Persian Gulf University, Bushehr 75169, Iran.
BarcelonaBeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain; Pompeu Fabra University, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain.
Neuroscience. 2021 Dec 15;479:192-205. doi: 10.1016/j.neuroscience.2021.10.025. Epub 2021 Nov 6.
In recent decades, our understanding of the molecular changes involved in neurodegenerative diseases has been transformed. Single-cell RNA sequencing and single-nucleus RNA sequencing technologies have been applied to provide cellular and molecular details of the brain at the single-cell level. This has expanded our knowledge of the central nervous system and provided insights into the molecular vulnerability of brain cell types and underlying mechanisms in neurodegenerative diseases. In this review, we highlight the recent advances and findings related to neurodegenerative diseases using these cutting-edge technologies.
近几十年来，我们对神经退行性疾病相关分子变化的理解发生了转变。单细胞 RNA 测序和单核 RNA 测序技术的应用，为我们提供了在单细胞水平上大脑的细胞和分子细节。这扩展了我们对中枢神经系统的认识，并深入了解了神经退行性疾病中脑细胞类型的分子脆弱性和潜在机制。在这篇综述中，我们强调了使用这些前沿技术在神经退行性疾病方面的最新进展和发现。
