Department of Physical Therapy, University of Alabama at Birmingham School of Health Professions, 360, 1720 2nd Ave S, Birmingham, AL 35233, United States.
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States.
Gait Posture. 2022 Jan;91:235-239. doi: 10.1016/j.gaitpost.2021.10.027. Epub 2021 Oct 25.
Persons with Parkinson's disease (PD) participate in low levels of physical activity. This has prompted interest in developing interventions targeting physical activity behavior in PD. However, the current cut-points to quantify moderate-to-vigorous physical activity (MVPA) developed for PD have been derived from a single, vertical axis using hip-worn accelerometers, and this cut-point may not be applicable for wrist-worn devices. Wrist-worn devices might improve accessibility and compliance with physical activity monitoring in PD.
What is the relationship between wrist-based activity counts and energy expenditure during treadmill walking in persons with PD? Do cut-points for quantifying time spent in MVPA differ between persons with PD and controls matched by age and sex?
The sample included 26 persons with mild-to-moderate PD (Hoehn and Yahr stages 2-3) and 27 age- and sex-matched controls. Participants completed three, 6-minute bouts of walking on a treadmill at three increasing speeds. Vector magnitude was measured using ActiGraph GT3X+ accelerometer worn on the more affected side for persons with PD and the non-dominant side for controls. The rate of oxygen consumption, or energy expenditure, was measured using a portable, open-circuit spirometry system.
Our results indicated a strong association between activity counts and energy expenditure for persons with PD and controls with R values of 0.94(0.07) and 0.95(0.06), respectively. Persons with PD had a cut-point of 2883(871) counts·min; this was significantly lower than the cut-point of 4389(1844) counts·min for controls.
We generated a PD-specific cut-point for wrist-worn ActiGraph accelerometers among persons with PD, and this was lower than controls. This disease-specific cut-point may provide more accurate measurements of time spent in MVPA in PD.
帕金森病（PD）患者的身体活动水平较低。这促使人们有兴趣开发针对 PD 患者身体活动行为的干预措施。然而，目前用于量化 PD 患者中中高强度身体活动（MVPA）的切点是使用髋部佩戴的加速度计从单个垂直轴得出的，并且该切点可能不适用于腕部佩戴的设备。腕部佩戴设备可能会提高 PD 患者身体活动监测的可及性和依从性。
在 PD 患者中，基于手腕的活动计数与跑步机行走时的能量消耗之间存在什么关系？用于量化 MVPA 时间的切点在 PD 患者和按年龄和性别匹配的对照组之间是否不同？
该样本包括 26 名轻度至中度 PD 患者（Hoehn 和 Yahr 分期 2-3 期）和 27 名年龄和性别匹配的对照组。参与者在三种不同速度的跑步机上完成了三次，每次 6 分钟的行走。对于 PD 患者，将 ActiGraph GT3X+ 加速度计佩戴在受影响程度较大的一侧，对于对照组，则佩戴在非优势侧，使用矢量幅度进行测量。使用便携式开路呼吸量测定系统测量耗氧量或能量消耗。
我们的结果表明，PD 患者和对照组的活动计数与能量消耗之间存在很强的关联，R 值分别为 0.94（0.07）和 0.95（0.06）。PD 患者的切点为 2883（871）计数·分钟；这明显低于对照组的 4389（1844）计数·分钟的切点。
我们为 PD 患者生成了一个特定于 PD 的腕戴 ActiGraph 加速度计切点，该切点低于对照组。该疾病特异性切点可能会更准确地测量 PD 患者中 MVPA 的时间。
