Zhang D, Wu X Y, Tao F B
Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University/MOE Key Laboratory of Population Health Across Life Cycl/Anhui Provincial Key Laboratory of Population Health＆Aristogenics, Hefei 230032, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2021 Nov 6;55(11):1346-1350. doi: 10.3760/cma.j.cn112150-20210906-00866.
Adolescence is not only an important stage of growth and development, but also a critical period for the formation of social and psychological cognition. The increasing incidence rate of depression in adolescents has caused serious global burden of disease. Allostatic load is a comprehensive index including multiple physiological system disorders. In the key stage of brain development, allostatic load plays an important role in the occurrence and development of mental diseases. This paper summarized the evaluation methods and prevalence of adolescent allostatic load, reviewed the relationship between allostatic load and adolescent depression, and revealed the possible physiological and neurobiological mechanisms, in order to provide scientific basis for prevention and control of adolescent depression.
青春期不仅是生长发育的重要阶段，也是社会和心理认知形成的关键时期。青少年抑郁症发病率的不断上升已造成严重的全球疾病负担。累积应激负荷是一个包括多种生理系统紊乱的综合指标。在大脑发育的关键阶段，累积应激负荷在精神疾病的发生和发展中起重要作用。本文总结了青少年累积应激负荷的评估方法和患病率，综述了累积应激负荷与青少年抑郁症的关系，并揭示了可能的生理和神经生物学机制，以期为青少年抑郁症的防控提供科学依据。
