Department of Chemistry, School of Science, Indrashil University, Mehsana, India.
Amity Stem cell Institute, Amity Medical School, Amity University Haryana, Amity Education Valley Pachgaon, Gurugram, India.
Prog Mol Biol Transl Sci. 2021;184:1-9. doi: 10.1016/bs.pmbts.2021.10.001. Epub 2021 Oct 22.
Idea of introducing aggregation-induced emission (AIE) fundamentally altered the scientific community's perception of classical photophysical processes. Many exciting new possibilities have been coming into light due to the emergence of AIE, such as ability of rapid detection and in analyzing variety of bioactive substances required to monitor the complexed biological processes. This also became a handy tool in elucidating the essential physiological and pathological behaviors of organisms. AIE luminogens (AIEgens) are luminous substances that are either weakly or non-emissive in organic solvents or hydrophobic environment alone, but it gives strong emissive when aggregated along with transforming polarities upon aggregation. Owing to the their outstanding advantages such as rapid turn on/off of high brightness emission, big Stokes shift, excellent photostability, and strong biocompatibility AIEgens have become first choice among bio-inspired probes in biomedicine. In the view of providing basic information on AIE, this chapter give a brief overview of aggregation-caused quenching (ACQ) phenomenon, approaches to transform ACQ to AIE phenomenon, photo-physics of AIE phenomenon, followed by known and reportedly novel AIE active molecules and their biomedical applications.
引入聚集诱导发光（AIE）的理念从根本上改变了科学界对经典光物理过程的认识。由于 AIE 的出现，出现了许多令人兴奋的新可能性，例如能够快速检测和分析各种生物活性物质，这些物质是监测复杂生物过程所必需的。这也成为阐明生物体基本生理和病理行为的有用工具。聚集诱导发光（AIE）材料是指在有机溶剂或单独的疏水环境中弱发光或不发光，但在聚集时会发射强荧光，并伴随着极性的转变。由于其具有快速开启/关闭高亮度发射、大斯托克斯位移、优异的光稳定性和强生物相容性等突出优点，AIE 材料已成为生物医学中生物启发探针的首选。鉴于提供有关 AIE 的基本信息，本章简要概述了聚集诱导猝灭（ACQ）现象、将 ACQ 转化为 AIE 现象的方法、AIE 现象的光物理，以及已知和报道的新型 AIE 活性分子及其在生物医学中的应用。
