Yamamoto Takeshi, Murakami Ryo, Suginome Michinori
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
Org Lett. 2021 Nov 19;23(22):8711-8716. doi: 10.1021/acs.orglett.1c03134. Epub 2021 Nov 9.
Helically chiral poly(quinoxaline-2,3-diyl)s bearing 4-(dipropylamino)pyridin-3-yl pendants at the 5-position of the quinoxaline ring () exhibited high catalytic activities and moderate to high selectivities (up to = 87) in the acylative kinetic resolution of secondary alcohols. The solvent-dependent helical chirality switching of between pure toluene and a 1:1 mixture of toluene and 1,1,2-trichloroethane enabled the preparation of either compound of a pair of enantiomerically pure alcohols (>99% ee) from a single catalyst.
在喹喔啉环5位带有4-(二丙基氨基)吡啶-3-基侧基的螺旋手性聚(喹喔啉-2,3-二基)()在仲醇的酰化动力学拆分中表现出高催化活性和中等到高的选择性(高达 = 87)。在纯甲苯与甲苯和1,1,2-三氯乙烷的1:1混合物之间， 存在溶剂依赖性螺旋手性转换，这使得能够从单一催化剂制备一对对映体纯醇中的任意一种化合物(>99% ee)。
