Phillips Katie M, Sedaghat Ahmad R
Department of Otolaryngology-Head and Neck Surgery, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Otolaryngol Head Neck Surg. 2022 May;166(5):985-992. doi: 10.1177/01945998211059732. Epub 2021 Nov 9.
The objective of this study was to determine whether depression and anxiety symptoms affect and confound scoring on the 22-item Sinonasal Outcome Test (SNOT-22), a commonly used outcome measure for chronic rhinosinusitis.
Prospective cross-sectional.
Tertiary care academic center.
240 participants completed the SNOT-22, from which nasal, sleep, ear/facial pain, and emotional subdomain scores were calculated. They also completed the 8-item Patient Health Questionnaire (PHQ-8) as a reflection of depression symptoms and 7-item Generalized Anxiety Disorder (GAD-7) questionnaire as a reflection of anxiety symptoms. Correlations were calculated between the 4 SNOT-22 subdomains and the PHQ-8 and GAD-7. Additionally, the predictive ability of subdomains and individual items of the SNOT-22 to predict depression and anxiety was calculated.
The SNOT-22 sleep and emotional subdomains most strongly correlated with the PHQ-8 and the GAD-7. The emotional and sleep subdomain scores were predictive of having depression or anxiety. An emotional subdomain score ≥4 had 62.5% sensitivity and 90.1% specificity for detecting depression and 78.8% sensitivity and 88.9% specificity for detecting anxiety. A sleep subdomain score ≥21 had 81.2% sensitivity and 71.4% specificity for detecting depression and 87.9% sensitivity and 68.6% specificity for detecting anxiety. The emotional subdomain item related to sadness and the sleep subdomain items related to functional impairment were most predictive of depression and anxiety.
The SNOT-22 emotional and sleep subdomain scores may be used to predict active depression and anxiety symptoms, especially when items related to sadness or functional impairment are scored with moderate burden.
本研究的目的是确定抑郁和焦虑症状是否会影响22项鼻鼻窦结局测试（SNOT-22）的评分并造成混淆，SNOT-22是慢性鼻-鼻窦炎常用的结局指标。
前瞻性横断面研究。
三级医疗学术中心。
240名参与者完成了SNOT-22测试，据此计算出鼻部、睡眠、耳/面部疼痛和情绪子域得分。他们还完成了8项患者健康问卷（PHQ-8）以反映抑郁症状，以及7项广泛性焦虑障碍问卷（GAD-7）以反映焦虑症状。计算了SNOT-22的4个子域与PHQ-8和GAD-7之间的相关性。此外，还计算了SNOT-22子域和单个项目预测抑郁和焦虑的能力。
SNOT-22睡眠和情绪子域与PHQ-8和GAD-7的相关性最强。情绪和睡眠子域得分可预测是否患有抑郁或焦虑。情绪子域得分≥4对检测抑郁的敏感性为62.5%，特异性为90.1%；对检测焦虑的敏感性为78.8%，特异性为88.9%。睡眠子域得分≥21对检测抑郁的敏感性为81.2%，特异性为71.4%；对检测焦虑的敏感性为87.9%，特异性为68.6%。与悲伤相关的情绪子域项目和与功能损害相关的睡眠子域项目对抑郁和焦虑的预测性最强。
SNOT-22情绪和睡眠子域得分可用于预测活跃的抑郁和焦虑症状，尤其是当与悲伤或功能损害相关的项目得分负担为中度时。
