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针对痴呆症照护者早晨激活缺陷的行为干预的适应和初步研究:安排活动和监测早晨(SAMM)。

Adaptation and Pilot Study of a Behavioral Intervention Targeting Morning Activation Deficits in Dementia Caregivers: Scheduling Activity and Monitoring Mornings (SAMM).

机构信息

Department of Psychiatry, School of Medicine (SFS, STS, CFR), University of Pittsburgh, Pittsburgh, PA.

Department of Occupational Therapy, School of Health and Rehabilitation Sciences (ASI, JR), University of Pittsburgh, Pittsburgh, PA.

出版信息

Am J Geriatr Psychiatry. 2022 Apr;30(4):494-503. doi: 10.1016/j.jagp.2021.09.017. Epub 2021 Oct 9.

Abstract

OBJECTIVES

Morning activation deficits (MADs) correlate with depression symptom persistence in older dementia caregivers. To clarify the potential of MADs as a target for depression interventions, we aimed to: 1) adapt an existing behavioral activation program, Engage therapy, to target mornings; and 2) evaluate effects on self-reported MADs and depression symptoms.

METHODS

While trialing the 9-week Engage adaption (targeting mornings) in six older dementia caregivers, we incorporated feedback and finalized an adapted program called Scheduling Activity and Monitoring Mornings (SAMM). We delivered the SAMM protocol to 13 dementia caregivers (all female; mean age = 69, standard deviation = 7). We report modifications made/rationale, as well as changes in subjective MADs (relevant items from the Composite Scale of Morningness) and depression symptoms (Patient Health Questionnaire - 9).

RESULTS

Using caregiver and expert input, we adapted the protocol to: include educational materials/content describing the potential relationship between morning inactivity and depression; target activity scheduling within 2 hours of awakening (preferably earlier); and focus only on the main components of morning activity scheduling, planning, and monitoring. This program was associated with decreases in subjective MADs averaging 29% at week 4, 52% at week 6, and 57% by week 9 (all p's <0.005). Initial depression symptoms were significantly reduced, by 62%, at week 9.

CONCLUSIONS

These preliminary findings suggest that subjective MADs can be modified pragmatically, and that doing so may have antidepressant effects. A controlled trial with measures of the putative mechanism is needed to clarify whether, and if so how, targeting MAD with SAMM causally perturbs depression's mechanisms.

摘要

目的

早晨激活缺陷(MADs)与老年痴呆症照顾者的抑郁症状持续存在相关。为了阐明 MADs 作为抑郁干预靶点的潜力,我们旨在:1)改编现有的行为激活计划,Engage 疗法,以针对早晨;2)评估对自我报告的 MADs 和抑郁症状的影响。

方法

在对六名老年痴呆症照顾者进行为期 9 周的 Engage 改编(针对早晨)试验时,我们结合了反馈并最终确定了一项名为“安排活动和监测早晨”(SAMM)的改编计划。我们向 13 名痴呆症照顾者(均为女性;平均年龄=69 岁,标准差=7 岁)提供了 SAMM 方案。我们报告了所做的修改/理由,以及主观 MADs(综合早晨量表的相关项目)和抑郁症状(患者健康问卷-9)的变化。

结果

使用照顾者和专家的意见,我们对方案进行了改编,包括:教育材料/内容,描述早晨不活动与抑郁之间的潜在关系;目标是在觉醒后 2 小时内(最好更早)进行活动安排;并仅关注早晨活动安排、计划和监测的主要内容。该方案与主观 MADs 的平均减少相关,在第 4 周减少 29%,第 6 周减少 52%,第 9 周减少 57%(均 p<0.005)。初始抑郁症状显著降低,第 9 周降低 62%。

结论

这些初步发现表明,主观 MADs 可以通过实用的方法进行修改,并且这样做可能具有抗抑郁作用。需要进行一项具有潜在机制测量的对照试验,以阐明是否以及如果是,通过 SAMM 靶向 MAD 是否会引起抑郁机制的因果变化。

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