Ruskoaho H, Raunio H
J Hypertens Suppl. 1986 Dec;4(6):S71-4.
The importance of changes in polyamine metabolism for myocardial growth was assessed by measuring the activity of ornithine decarboxylase (ODC) and the polyamines spermidine, spermine and putrescine in hearts from spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. The rats were 30-weeks-old and had received 6 weeks treatment with either minoxidil (0.08 mg/ml) or alpha-methyldopa (5 mg/ml in drinking water). Left ventricular ODC activity was greater in the untreated SHR than the WKY rats at 4, 16 and 20 weeks of age. Spermidine content was consistently raised and spermine content reduced in the untreated SHR left ventricles, resulting in the high spermidine/spermine ratios characteristic of rapidly growing systems. Minoxidil treatment increased left ventricular weight and spermidine (83 and 61% in WKY and SHR rats, respectively) and spermine (44 and 28%) content. Methyldopa also caused an increase in left ventricular spermidine content (30 and 57% in WKY and SHR rats, respectively) despite a marked reduction in ventricular mass. Thus the ventricular hypertrophy in SHR rats is accompanied by enhanced synthesis and accumulation of polyamines. The fact that myocardial spermidine content increased during methyldopa treatment, which reduced myocardial mass, suggests that the polyamines are not causally related to the development of ventricular hypertrophy.
通过测量自发性高血压大鼠（SHR）和Wistar-Kyoto大鼠（WKY）心脏中鸟氨酸脱羧酶（ODC）的活性以及多胺亚精胺、精胺和腐胺的含量，评估了多胺代谢变化对心肌生长的重要性。这些大鼠为30周龄，接受了6周的米诺地尔（0.08mg/ml）或α-甲基多巴（5mg/ml于饮用水中）治疗。在4周、16周和20周龄时，未经治疗的SHR左心室ODC活性高于WKY大鼠。未经治疗的SHR左心室中亚精胺含量持续升高，精胺含量降低，导致快速生长系统特有的高亚精胺/精胺比值。米诺地尔治疗增加了左心室重量以及亚精胺（WKY和SHR大鼠分别增加83%和61%）和精胺（分别增加44%和28%）含量。尽管心室质量显著降低，但甲基多巴也导致左心室亚精胺含量增加（WKY和SHR大鼠分别增加30%和57%）。因此，SHR大鼠的心室肥大伴随着多胺合成和积累的增强。在甲基多巴治疗期间心肌亚精胺含量增加，而心肌质量降低，这一事实表明多胺与心室肥大的发展没有因果关系。
