低剂量A型肉毒毒素对过度活动型埃勒斯-当洛综合征颈部肌张力障碍的影响
The Effect of Low Dose OnabotulinumtoxinA on Cervical Dystonia in Hypermobile Ehlers-Danlos Syndrome.
作者信息
Wang Tina J, Stecco Antonio, Dashtipour Khashayar
机构信息
Loma Linda University School of Medicine, Department of Physical Medicine & Rehabilitation, US.
New York University School of Medicine, Department of Rehabilitation, US.
出版信息
Tremor Other Hyperkinet Mov (N Y). 2021 Oct 25;11:42. doi: 10.5334/tohm.647. eCollection 2021.
BACKGROUND
Many patients with hypermobile Ehlers-Danlos Syndrome (EDS) suffer from cervical dystonia. Intramuscular injection of botulinum toxin may exacerbate myeloradiculopathy or atlantoaxial subluxation in this patient population.
CASE
Three patients with hypermobile EDS underwent low-dose OnabotulinumtoxinA injections for cervical dystonia into myofascial sites selected using Fascial Manipulation diagnostic sequencing technique. All patients improved in clinical symptoms without complications.
RESULTS
Patients clinically improved on the TWSTRS by 16 points with demonstrated changes in deep fascia thickness decrease of 0.28 mm.
DISCUSSION
Low-dose OnabotulinumtoxinA injections into carefully selected sites is a safe and effective treatment in hypermobile EDS patients suffering from cervical dystonia.
背景
许多患有活动度过高型埃勒斯-当洛综合征（EDS）的患者患有颈部肌张力障碍。在这一患者群体中，肌肉注射肉毒杆菌毒素可能会加重脊髓神经根病或寰枢椎半脱位。
病例
三名患有活动度过高型EDS的患者接受了低剂量的A型肉毒毒素注射，用于治疗颈部肌张力障碍，注射部位是使用筋膜手法诊断测序技术选择的肌筋膜部位。所有患者的临床症状均有改善，且无并发症。
结果
患者的多伦多西部痉挛性斜颈评分（TWSTRS）在临床上提高了16分，同时深筋膜厚度减少了0.28毫米。
讨论
在患有颈部肌张力障碍的活动度过高型EDS患者中，在精心选择的部位进行低剂量的A型肉毒毒素注射是一种安全有效的治疗方法。
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