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通过完整基因座替换剖析该基因在口器多样化中的进化作用。

Dissecting the evolutionary role of the gene in mouthpart diversification by full locus replacement.

作者信息

Auradkar Ankush, Bulger Emily A, Devkota Sushil, McGinnis William, Bier Ethan

机构信息

Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA.

Tata Institute for Genetics and Society-UCSD, La Jolla, CA 92093-0335, USA.

出版信息

Sci Adv. 2021 Nov 12;7(46):eabk1003. doi: 10.1126/sciadv.abk1003. Epub 2021 Nov 10.

DOI:10.1126/sciadv.abk1003
PMID:34757777
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8580299/
Abstract

genes determine positional codes along the head-to-tail axis. Here, we replaced the entire () locus, which controls the development of the proboscis and maxillary palps, with that from , a related species with highly modified mouthparts. The replacement rescues most aspects of adult proboscis morphology; however, the shape and orientation of maxillary palps were modified, resembling and closely related species. Expressing the Pb protein in the pattern fully rescued morphology. However, the expression pattern directed by cis-regulatory sequences differed from that of in cells that produce altered maxillary structures, indicating that regulatory sequences can evolve in related species to alter morphology.

摘要

基因决定了沿头尾轴的位置编码。在这里，我们用来自一个口器高度特化的相关物种的基因座替换了整个（）基因座，该基因座控制着喙和下颚须的发育。这种替换挽救了成年喙形态的大部分方面；然而，下颚须的形状和方向发生了改变，类似于（）及其近缘物种。以（）模式表达Pb蛋白完全挽救了（）的形态。然而，由（）顺式调控序列指导的表达模式在产生改变的下颚结构的细胞中与（）的不同，这表明（）调控序列在相关物种中可以进化以改变形态。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa27/8580299/bc125ad742bd/sciadv.abk1003-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa27/8580299/e1a771f0b569/sciadv.abk1003-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa27/8580299/3a83b383b55c/sciadv.abk1003-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa27/8580299/3d4795a9d1ee/sciadv.abk1003-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa27/8580299/bc125ad742bd/sciadv.abk1003-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa27/8580299/e1a771f0b569/sciadv.abk1003-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa27/8580299/3a83b383b55c/sciadv.abk1003-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa27/8580299/3d4795a9d1ee/sciadv.abk1003-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa27/8580299/bc125ad742bd/sciadv.abk1003-f4.jpg

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