Morant R, Rüttner J R
Schweiz Med Wochenschr. 1987 Jun 20;117(25):952-7.
57 cases of late sequelae after diagnostic thorotrast exposure (recorded between 1944 and 1982 in Zurich) are presented. The alpha-ray-emitting contrast medium thorotrast is carcinogenic and fibrogenic. Malignant tumors occurred in about half of our cases after a latency period of 14 to 44 years, comprising 8 primary liver carcinomas, 2 carcinomas of the bile ducts, 3 malignant hemangioendotheliomas of the liver, 10 renal pelvic carcinomas and sarcomas, and one acute myelogenous leukemia. Further, cirrhosis and fibrosis of the liver and paravascular "thorotrastoma" were observed. The late effects of thorotrast are a negative example of avoidable radiation injuries to man.
本文报告了57例因诊断性使用钍造影剂而导致的晚期后遗症病例（记录于1944年至1982年期间，位于苏黎世）。发射α射线的造影剂钍造影剂具有致癌性和致纤维化性。在潜伏期14至44年后，约一半的病例发生了恶性肿瘤，包括8例原发性肝癌、2例胆管癌、3例肝脏恶性血管内皮瘤、10例肾盂癌和肉瘤，以及1例急性髓细胞白血病。此外，还观察到了肝脏的肝硬化和纤维化以及血管旁“钍造影瘤”。钍造影剂的晚期效应是人类可避免的辐射损伤的一个反面例子。
