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COVID-19 大流行对艾滋病毒护理、抗逆转录病毒治疗依从性和病毒抑制的影响:来自乌干达的一项观察性队列研究。

Impact of the COVID-19 Pandemic on Use of HIV Care, Antiretroviral Therapy Adherence, and Viral Suppression: An Observational Cohort Study From Uganda.

机构信息

Department of Economics, Sociology and Statistics, RAND Corporation, Santa Monica, CA.

Pardee RAND Graduate School, Santa Monica, CA.

出版信息

J Acquir Immune Defic Syndr. 2021 Dec 15;88(5):448-456. doi: 10.1097/QAI.0000000000002811.


DOI:10.1097/QAI.0000000000002811
PMID:34757973
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8575089/
Abstract

INTRODUCTION: Recent studies project thousands of additional AIDS-related deaths because of COVID-19-related disruptions in HIV care. However, the extent to which disruptions in care have materialized since the start of the pandemic is not well understood. METHODS: We use electronic health records to investigate how the pandemic has affected clinic visits, patients' antiretroviral therapy (ART) supply, and viral suppression for a cohort of 14,632 HIV clients from a large HIV clinic in Kampala, Uganda. We complement this with an analysis of electronically measured longitudinal ART adherence data from a subcohort of 324 clients. RESULTS: Clinic visits decreased by more than 50% after a national lockdown started. The risk of patients running out of ART on a given day increased from 5% before the lockdown to 25% 3 months later (Relative Risk Ratio of 5.11, 95% confidence interval: 4.99 to 5.24) and remained higher than prelockdown 6 months later at 13% (Relative Risk Ratio of 2.60; 95% confidence interval: 2.52 to 2.70). There was no statistically significant change in electronically measured adherence or viral suppression. CONCLUSION: We document substantial gaps in HIV care after the start of the COVID-19 pandemic in Uganda. This suggests that measures to improve access should be explored as the pandemic persists. However, ART adherence was unaffected for the subcohort for whom we measured electronic adherence. This suggests that some clients may have stockpiles of ART tablets from previous prescriptions that allowed them to keep taking their medication even when they could not visit the clinic for ART refills.

摘要

简介:由于 COVID-19 对艾滋病毒护理的干扰,最近的研究预计会有数千例与艾滋病相关的额外死亡。然而,自大流行开始以来,护理中断的程度还没有得到很好的理解。

方法:我们使用电子健康记录来调查大流行如何影响乌干达坎帕拉一家大型艾滋病毒诊所的 14632 名艾滋病毒患者的就诊情况、他们的抗逆转录病毒治疗 (ART) 供应以及病毒抑制情况。我们还对 324 名患者的亚组进行了电子测量的纵向 ART 依从性数据分析。

结果:国家封锁开始后,就诊次数减少了 50%以上。患者在给定日期用完 ART 的风险从封锁前的 5%增加到 3 个月后的 25%(相对风险比为 5.11,95%置信区间:4.99 至 5.24),6 个月后仍高于封锁前的水平,为 13%(相对风险比为 2.60;95%置信区间:2.52 至 2.70)。电子测量的依从性或病毒抑制率没有统计学上的显著变化。

结论:我们记录了乌干达 COVID-19 大流行开始后艾滋病毒护理的重大差距。这表明,随着大流行的持续,应探索改善获得护理的措施。然而,对于我们测量电子依从性的亚组,ART 依从性没有受到影响。这表明,一些患者可能有以前处方的 ART 片剂库存,这使他们即使无法前往诊所续药,也能继续服用药物。

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本文引用的文献

[1]
The role of material deprivations in determining ART adherence: Evidence from a conjoint analysis among HIV-positive adults in Uganda.

PLOS Glob Public Health. 2022-8-17

[2]
Transient Reductions in Human Immunodeficiency Virus (HIV) Clinic Attendance and Food Security During the Coronavirus Disease 2019 (COVID-19) Pandemic for People Living With HIV in 4 African Countries.

Clin Infect Dis. 2021-11-16

[3]
HIV Care Experiences During the COVID-19 Pandemic: Mixed-Methods Telephone Interviews with Clinic-Enrolled HIV-Infected Adults in Uganda.

AIDS Behav. 2021-1

[4]
A Rapid Qualitative Assessment of the Impact of the COVID-19 Pandemic on a Racially/Ethnically Diverse Sample of Gay, Bisexual, and Other Men who Have Sex with Men Living with HIV in the US South.

AIDS Behav. 2021-1

[5]
Potential effects of disruption to HIV programmes in sub-Saharan Africa caused by COVID-19: results from multiple mathematical models.

Lancet HIV. 2020-8-6

[6]
A conceptual model for understanding the rapid COVID-19-related increase in food insecurity and its impact on health and healthcare.

Am J Clin Nutr. 2020-11-11

[7]
Potential impact of the COVID-19 pandemic on HIV, tuberculosis, and malaria in low-income and middle-income countries: a modelling study.

Lancet Glob Health. 2020-7-13

[8]
Attendance to HIV Antiretroviral Collection Clinic Appointments During COVID-19 Lockdown. A Single Center Study in Kigali, Rwanda.

AIDS Behav. 2020-12

[9]
HIV and Food Insecurity: A Syndemic Amid the COVID-19 Pandemic.

AIDS Behav. 2020-10

[10]
Characterizing the Impact of COVID-19 on Men Who Have Sex with Men Across the United States in April, 2020.

AIDS Behav. 2020-7

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