Division of Nephrology, Centre Hospitalier de l'Université de Montréal, QC, Canada.
Department of Nephrology, Princess Alexandra Hospital, Brisbane, QLD, Australia.
Perit Dial Int. 2022 Jul;42(4):403-414. doi: 10.1177/08968608211056242. Epub 2021 Nov 10.
The Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) is an international, prospective study following persons treated by peritoneal dialysis (PD) to identify modifiable practices associated with improvements in PD technique and person survival. The aim of this study was to assess the representativeness of the Australian cohort included in PDOPPS compared to the complete Australian PD population, as reported to the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry.
Adults with at least one PD treatment reported to ANZDATA Registry during the census period of PDOPPS Phase I (November 2014 to April 2018) were compared to the Australian PDOPPS cohort. The primary outcomes were the representativeness of centres and persons. Secondary outcomes explored the association of person characteristics with consent to study participation.
After data linkage, 511 PDOPPS participants were compared to 5616 Australians treated with PD. Within centres eligible for PDOPPS, selected centres were similar to other Australian centres. The PDOPPS participants' cohort tended to include older persons, more males, a higher proportion of Caucasians and more persons with higher socioeconomic advantage compared to the Australian PD population. Differences in distribution across sex and ethnicities between the PDOPPS cohort and the overall PD population were in part due to the selection and consent processes, during which females and non-Caucasians were more likely to not consent to PDOPPS participation.
Sampling methods used in PDOPPS allowed for good national representativeness of the included centres. However, representativeness of the unweighted PDOPPS sample was suboptimal in regard to some participant characteristics.
腹膜透析结局和实践模式研究（PDOPPS）是一项国际性的前瞻性研究，对接受腹膜透析（PD）治疗的患者进行随访，以确定与 PD 技术改进和患者生存相关的可改变实践。本研究的目的是评估纳入 PDOPPS 的澳大利亚队列与向澳大利亚和新西兰透析和移植（ANZDATA）登记处报告的完整澳大利亚 PD 人群的代表性。
在 PDOPPS 第一阶段（2014 年 11 月至 2018 年 4 月）的普查期间，向 ANZDATA 登记处报告的至少接受过一次 PD 治疗的成年人与澳大利亚 PDOPPS 队列进行了比较。主要结局指标是中心和人员的代表性。次要结局指标探讨了患者特征与同意参与研究的关系。
在数据链接后，将 511 名 PDOPPS 参与者与 5616 名接受 PD 治疗的澳大利亚人进行了比较。在有资格参加 PDOPPS 的中心内，选定的中心与其他澳大利亚中心相似。与澳大利亚 PD 人群相比，PDOPPS 参与者的队列往往包括年龄较大的人、更多的男性、更高比例的白种人和更多社会经济地位较高的人。PDOPPS 队列与总体 PD 人群在性别和族裔分布上的差异部分归因于选择和同意过程，在此过程中，女性和非白种人更有可能不同意参与 PDOPPS。
PDOPPS 中使用的抽样方法允许纳入的中心具有良好的全国代表性。然而，未加权 PDOPPS 样本在一些参与者特征方面的代表性并不理想。
