AlRaddadi Rawya Ibrahim Rabeh, Alamri Razan Jamaan Nafaa, Shebli Weam Talal Yehya, Fallatah Emad Ibrahim Yagoub, Alhujaily Ahmed Safar, Mohamed Hiba Salaheldin, Alotibi Mohammad Kdaimes H
Department of Biology, College of Science, Taibah University, Madinah, Saudi Arabia.
Department of Oncology, King Fahad Hospital, Madinah, Saudi Arabia.
Saudi J Biol Sci. 2021 Nov;28(11):6112-6115. doi: 10.1016/j.sjbs.2021.07.005. Epub 2021 Jul 10.
Fibroblast growth factor receptor 2 is a protein encoded by gene and plays an important role in cellular growth. This study was conducted to investigate a potential association of rs2981582 with breast cancer. DNA was obtained from 137 Formalin-fixed, paraffin-embedded tumors and 98 normal breast tissue samples. Genotypes were carried out with PCR-RFLP. The odds ratio and 95% confidence interval (CI) were used to evaluate the power of the associations. A significant association between FGFR2 rs2981582 C allele and susceptibility to breast cancer was found (p-value < 0.0001, Odds Ratio = 2.3, %95 CI (1.5-3.0). No significant differences in FGFR2 rs2981582 genotypes and alleles distribution among breast patients with different hormonal receptor status ( > 0.05) were detected. However, a significant difference was found in genotypes and alleles distribution in ER+, PR- and HER2 between breast cancer cases and controls. This study showed an association of FGFR2 rs2981582T/C with breast cancer in Saudi women, further large study is required to validate the results.
成纤维细胞生长因子受体2是一种由基因编码的蛋白质，在细胞生长中起重要作用。本研究旨在调查rs2981582与乳腺癌之间的潜在关联。从137份福尔马林固定、石蜡包埋的肿瘤组织和98份正常乳腺组织样本中获取DNA。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）进行基因分型。比值比和95%置信区间（CI）用于评估关联强度。发现FGFR2 rs2981582 C等位基因与乳腺癌易感性之间存在显著关联（p值<0.0001，比值比=2.3，95%CI（1.5-3.0））。在不同激素受体状态的乳腺癌患者中，FGFR2 rs2981582基因型和等位基因分布无显著差异（p>0.05）。然而，在乳腺癌病例和对照之间，ER+、PR-和HER2的基因型和等位基因分布存在显著差异。本研究表明沙特女性中FGFR2 rs2981582T/C与乳腺癌有关联，需要进一步的大规模研究来验证结果。
