Che Denis Nchang, Shin Jae Young, Kang Hyun Ju, Cho Byoung Ok, Park Ji Hyeon, Wang Feng, Hao Suping, Sim Jae Suk, Sim Dong Jun, Jang Seon Il
Institute of Health Science Jeonju University Jeonju-si Republic of Korea.
Department of Food Science and Technology Jeonbuk National University Jeonju-si Republic of Korea.
Food Sci Nutr. 2021 Sep 1;9(11):6060-6068. doi: 10.1002/fsn3.2548. eCollection 2021 Nov.
The objective of this study was to determine biological effects of extract and its main component cirsimaritin on high-fat diet (HFD)-induced metabolic dysfunction-associated fatty liver disease (MAFLD) in a mouse model. Mice were fed with a HFD to induce MAFLD and simultaneously administered with . extract (CJE) or cirsimaritin. Various MAFLD biomarkers were evaluated using biological methods. Results demonstrated that triglyceride, aspartate aminotransferase, alanine aminotransferase, and malondialdehyde levels in the liver of mice were significantly reduced upon administration of CJE or cirsimaritin. Treatment with CJE or cirsimaritin also reduced the severity of liver injury in the experimental mouse model of MAFLD by inhibiting hepatic steatosis, oxidative stress, inflammation, and liver fibrosis. These results demonstrate that CJE and cirsimaritin as its main compound have a preventive action against the progression of hepatic steatosis to fibrosis and cirrhosis. Our study suggests that CJE and cirsimaritin might be promising agents for preventing and/or treating MAFLD.
本研究的目的是在小鼠模型中确定提取物及其主要成分 cirsimaritin 对高脂饮食（HFD）诱导的代谢功能障碍相关脂肪性肝病（MAFLD）的生物学效应。给小鼠喂食高脂饮食以诱导 MAFLD，并同时给予提取物（CJE）或 cirsimaritin。使用生物学方法评估各种 MAFLD 生物标志物。结果表明，给予 CJE 或 cirsimaritin 后，小鼠肝脏中的甘油三酯、天冬氨酸转氨酶、丙氨酸转氨酶和丙二醛水平显著降低。CJE 或 cirsimaritin 治疗还通过抑制肝脂肪变性、氧化应激、炎症和肝纤维化，减轻了 MAFLD 实验小鼠模型中的肝损伤严重程度。这些结果表明，CJE 和作为其主要化合物的 cirsimaritin 对肝脂肪变性向纤维化和肝硬化的进展具有预防作用。我们的研究表明，CJE 和 cirsimaritin 可能是预防和/或治疗 MAFLD 的有前景的药物。
