Kushlinskiĭ N E, Siniukov P A, Petrovichev N N, Vasil'ev A V
Arkh Patol. 1987;49(5):52-7.
"Free" and "total" (the sum of the occupied and free sites of binding) androgen receptors (AR) in the cytosolic fraction of 51 bone tumors were studied with reference to their histologic structure and treatment. "Free" AR were found in chondrosarcomas and osteogenic sarcomas previously treated two times more frequently than in untreated tumors. It is found that in untreated osteogenic sarcomas much more "total" AR in the cytoplasm are occupied with an endogenic androgen than in the treated tumors. More than a half of "total" AR in the cytoplasm of chondrosarcomas are bound with an endogenic androgen. The authors believe chondrosarcomas and osteogenic sarcomas treated with radiation and adriamycin to be more susceptible to the androgens than untreated osteogenic sarcomas. The evaluation of the susceptibility to the androgens of bone tumors which are followed or possibly stipulated by the metabolic disturbances of sex steroid hormones will be of value in the study of bone tumor hormonal regulation.
对51例骨肿瘤细胞溶质部分的“游离”和“总”（结合位点的占据和游离位点之和）雄激素受体（AR）进行了研究，并参考了它们的组织结构和治疗情况。在先前接受过两次治疗的软骨肉瘤和成骨肉瘤中发现“游离”AR的频率比未治疗的肿瘤高出两倍。研究发现，在未治疗的成骨肉瘤中，细胞质中“总”AR被内源性雄激素占据的比例比治疗后的肿瘤要高得多。软骨肉瘤细胞质中超过一半的“总”AR与内源性雄激素结合。作者认为，接受放疗和阿霉素治疗的软骨肉瘤和成骨肉瘤比未治疗的成骨肉瘤对雄激素更敏感。对骨肿瘤雄激素敏感性的评估，若其受到或可能由性类固醇激素代谢紊乱所引发，将对骨肿瘤激素调节的研究具有重要价值。
