Spurway Jacqueline, Logan Patricia, Pak Sok Cheon, Nielsen Sharon
Medical Imaging Department Orange Health Service PO Box 319 Orange New South Wales 2800 Australia.
School of Biomedical Sciences Charles Sturt University Locked Bag 49 Dubbo New South Wales 2830 Australia.
Australas J Ultrasound Med. 2017 Aug 20;20(4):155-162. doi: 10.1002/ajum.12060. eCollection 2017 Nov.
To construct gestational age (GA)-related reference ranges of the intra-amniotic umbilical cord vein (UCV) diameter, peak velocity (PV) and blood flow (Qucv) using a Central West New South Wales population.
This was a prospective, quasi-experimental study of low risk, singleton pregnancies (n = 321) between 16 and 42 weeks of gestation. Participation was voluntary following informed consent. The UCV diameter and PV were measured using B mode and duplex Doppler respectively, and Qucv calculated. Percentile values and reference range graphs were established using quantile regression modelling in R statistical software. Intraclass correlation coefficients (ICCs) were calculated to assess the intra and intersonographer reliability.
Reference ranges for the UCV diameter, PV and Qucv were established and graphed. All three UCV measurements increased with advancing GA, with both diameter and Qucv exhibiting a decline in the late third trimester. The intrasonographer and intersonographer ICCs for the UCV diameter and PV showed almost perfect agreement within and between sonographers.
Gestational age-related reference ranges for the UCV diameter, PV and Qucv were developed using quantile regression from a cohort of low risk, singleton pregnancies in Central West NSW. These reference ranges have the potential to assist in the diagnosis and monitoring of fetal growth restriction.
利用新南威尔士州中西部人群构建羊膜腔内脐静脉（UCV）直径、峰值流速（PV）和血流量（Qucv）与孕周（GA）相关的参考范围。
这是一项对16至42周妊娠的低风险单胎妊娠（n = 321）进行的前瞻性、准实验性研究。在获得知情同意后，参与是自愿的。分别使用B模式和双功多普勒测量UCV直径和PV，并计算Qucv。使用R统计软件中的分位数回归模型建立百分位数和参考范围图。计算组内相关系数（ICC）以评估超声检查者内部和之间的可靠性。
建立了UCV直径、PV和Qucv的参考范围并绘制了图表。所有三项UCV测量值均随孕周增加而增加，直径和Qucv在妊娠晚期均呈下降趋势。超声检查者内部和之间的UCV直径和PV的ICC显示超声检查者内部和之间几乎完全一致。
利用新南威尔士州中西部低风险单胎妊娠队列的分位数回归，建立了UCV直径、PV和Qucv与孕周相关的参考范围。这些参考范围有可能有助于胎儿生长受限的诊断和监测。
