镰状细胞病患儿的经颅多普勒检查：五年筛查经验
Transcranial Doppler in children with sickle cell disease: Five years of screening experience.
作者信息
Crow Amanda
机构信息
The Children's Hospital at Westmead Cnr Hawkesbury Rd Hainsworth St Westmead New South Wales 2145 Australia.
出版信息
Australas J Ultrasound Med. 2020 Feb 20;23(1):39-46. doi: 10.1002/ajum.12192. eCollection 2020 Feb.
INTRODUCTION
Sickle cell disease (SCD) is an autosomal recessive, inherited disorder of haemoglobin. Children with sickle cell disease (SCD) are at risk of vascular occlusions. If this occurs in the brain, it can result in stroke. Stroke is the leading cause of death and disability in children with SCD.Transcranial Doppler (TCD) has been shown to accurately predict those children at risk of stroke so appropriate preventative treatment can commence.
METHOD
TCD screening with a non-imaging Doppler machine to assess stroke risk has been in operation at our institution for 5 years. Eighty-eight patients attending the haematology clinic for SCD are scanned annually. If abnormal velocities are found, repeat scans are performed at close interval to ensure results are reproducible.
RESULTS
No child has had a stroke since the start of our screening. Seven of the eighty-eight patients have shown high velocities on annual screening.
CONCLUSION
The introduction of a TCD programme at out institution has identified children at risk of stroke so they can be closely monitored and potentially receive prophylactic treatment.
引言
镰状细胞病（SCD）是一种常染色体隐性遗传性血红蛋白疾病。患有镰状细胞病（SCD）的儿童有血管闭塞的风险。如果发生在脑部，可能会导致中风。中风是患有SCD的儿童死亡和残疾的主要原因。经颅多普勒（TCD）已被证明能够准确预测那些有中风风险的儿童，以便开始适当的预防性治疗。
方法
在我们机构，使用非成像多普勒机器进行TCD筛查以评估中风风险已开展5年。每年对88名到血液科门诊就诊的SCD患者进行扫描。如果发现速度异常，则在短时间间隔内重复扫描以确保结果可重复。
结果
自我们的筛查开始以来，没有儿童发生中风。88名患者中有7名在年度筛查中显示速度较高。
结论
在我们机构引入TCD项目已识别出有中风风险的儿童，因此可以对他们进行密切监测并可能接受预防性治疗。
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