Gibbons B, Czepulkowski B, Tucker J, Simpson E, Amess J A, Young B D, Lister T A
Cancer Genet Cytogenet. 1987 Oct;28(2):287-92. doi: 10.1016/0165-4608(87)90215-9.
A series of four patients with small deletions of the short arm of chromosome #11 is presented. In two of these patients, deletion of 11p was the sole karyotypic abnormality. When compared with similar reported cases an association with FAB type M4 is apparent. Such cases may often be undocumented, because the deletions can be subtle. One patient with erythroleukemia shows an inversion of chromosome #11 involving band 11p15. Because the patients' fetal hemoglobin (HbF) became raised during the course of the disease, it is postulated that the hemoglobin beta chain gene at 11p15 may have been disrupted.
本文报告了4例11号染色体短臂小片段缺失的患者。其中2例患者，11p缺失是唯一的核型异常。与类似的报道病例相比，与FAB M4型明显相关。此类病例可能常未被记录，因为缺失可能很细微。1例红白血病患者显示11号染色体倒位，涉及11p15带。由于患者的胎儿血红蛋白（HbF）在病程中升高，推测11p15处的血红蛋白β链基因可能已被破坏。
