Yang Shu-Quan, Fan De-Hui, Yuan Zhi-Xian, Su Mei-Yi, Zhang Zhen-Ning, Lin Ying, Lin Hu-Guang
Fifth Clinical Medical College of Guangzhou University of CM, Guangzhou 510095, Guangdong Province, China; Department of Acupuncture-Moxibustion, Second Hospital of TCM of Guangdong Province, Guangzhou 510095.
Department of Acupuncture-Moxibustion, Second Hospital of TCM of Guangdong Province, Guangzhou 510095.
Zhongguo Zhen Jiu. 2021 Nov 12;41(11):1231-5. doi: 10.13703/j.0255-2930.20201106-k0002.
To compare the clinical efficacy of abdominal acupoint thread embedding therapy based on "brain-intestinal connection" combined with donepezil hydrochloride tablets and oral donepezil hydrochloride tablets alone for mild-to-moderate Alzheimer's disease (AD) and observe its effects on amyloid precursor protein (APP) and β-amyloid protein (Aβ).
Sixty patients with AD were randomly divided into an observation group (30 cases, 3 cases dropped off) and a control group (30 cases, 3 cases dropped off). The patients in the control group were treated with donepezil hydrochloride tablets (5 mg per day); based on the treatment in the control group, the patients in the observation group were treated with abdominal acupoint thread embedding therapy at Zhongwan (CV 12), Xiawan (CV 10), Huaroumen (ST 24), Wailing (ST 26), Daheng (SP 15), etc., once every 10 days. Both groups were treated for 2 months. The mini-mental state examination (MMSE), Alzheimer's disease assessment scale-cognitive subscale (ADAS-Cog), activity of daily living scale (ADL), neuropsychiatric inventory questionnaire (NPI) as well as the serum levels of APP and Aβ were observed before and after treatment in the two groups.
After treatment, the MMSE scores in the two groups were higher than those before treatment (<0.05), and the ADAS-Cog, ADL and NPI scores were lower than those before treatment (<0.05). After treatment, the MMSE score in the observation group was higher than that in the control group (<0.05), and the ADAS-Cog, ADL and NPI scores were lower than those in the control group (<0.05). After treatment, the serum levels of APP and Aβ were lower than those before treatment (<0.05), and the serum levels of APP and Aβ in the observation group was lower than those in the control group (<0.05).
The abdominal acupoint thread embedding therapy based on the theory of "brain-intestinal connection" combined with donepezil hydrochloride tablets can improve cognitive function, self-care ability of daily life and mental behavior, and reduce the serum levels of APP and Aβ in patients with mild-to-moderate AD, which have superior clinical effect to donepezil hydrochloride tablets alone.
比较基于“脑肠相通”理论的腹部穴位埋线疗法联合盐酸多奈哌齐片与单纯口服盐酸多奈哌齐片治疗轻中度阿尔茨海默病（AD）的临床疗效，并观察其对淀粉样前体蛋白（APP）和β淀粉样蛋白（Aβ）的影响。
将60例AD患者随机分为观察组（30例，脱落3例）和对照组（30例，脱落3例）。对照组患者口服盐酸多奈哌齐片（每日5mg）；观察组患者在对照组治疗基础上，采用腹部穴位埋线疗法，穴位选取中脘（CV12）、下脘（CV10）、滑肉门（ST24）、外陵（ST26）、大横（SP15）等，每10天治疗1次。两组均治疗2个月。观察两组治疗前后简易精神状态检查表（MMSE）、阿尔茨海默病评估量表认知分量表（ADAS-Cog）、日常生活活动能力量表（ADL）、神经精神问卷（NPI）以及血清APP、Aβ水平。
治疗后，两组MMSE评分均高于治疗前（P<0.05），ADAS-Cog、ADL及NPI评分均低于治疗前（P<0.05）。治疗后，观察组MMSE评分高于对照组（P<0.05），ADAS-Cog、ADL及NPI评分低于对照组（P<0.05）。治疗后，两组血清APP、Aβ水平均低于治疗前（P<0.05），且观察组血清APP、Aβ水平低于对照组（P<0.05）。
基于“脑肠相通”理论的腹部穴位埋线疗法联合盐酸多奈哌齐片可改善轻中度AD患者的认知功能、日常生活自理能力及精神行为，降低血清APP、Aβ水平，临床疗效优于单纯口服盐酸多奈哌齐片。
