University of Tennessee, Knoxville, TN, USA.
University of Georgia, Athens, GA, USA. Lieske is now with IDEXX, Columbus, OH, USA.
Vet Pathol. 2022 Mar;59(2):264-268. doi: 10.1177/03009858211048621. Epub 2021 Nov 11.
This report describes periarticular plasma cell tumors with abundant amyloid in 11 cats. The tarsus was the most commonly affected joint (10/11), and the masses were often circumferential around the tarsal joint, involving the dermis and subcutis. The 2 cases in which synovium was examined had neoplastic cells expanding the synovium. Three of the 5 cases staged radiographically had bony lysis of the affected joint. Cutaneous biopsy specimens often consisted of more amyloid than plasma cells, making the diagnosis difficult on small samples. Follow-up information was available in 7 cases; in those cases, the median survival was 194 days (range 53-671 days). Four cases had confirmed metastases, most often to regional lymph nodes, liver, and spleen. Although canine cutaneous plasma cell tumors are typically benign, those with abundant amyloid surrounding the joints of cats may involve deeper tissues and have a more aggressive behavior. These tumors can be difficult to diagnose due to low cellularity and abundant amyloid.
本报告描述了 11 例猫关节周围富含淀粉样物质的浆细胞瘤。跗关节是最常受累的关节（11 例中的 10 例），肿块常环绕跗关节呈环状，累及真皮和皮下组织。检查滑膜的 2 例中有肿瘤细胞使滑膜扩张。影像学分期的 5 例中有 3 例受累关节有骨溶解。皮肤活检标本通常含有比浆细胞更多的淀粉样物质，使得小样本的诊断变得困难。在 7 例可获得随访信息的病例中，中位生存时间为 194 天（范围 53-671 天）。4 例有确认的转移，最常见的转移部位是局部淋巴结、肝脏和脾脏。虽然犬皮肤浆细胞瘤通常为良性，但那些在猫关节周围有大量淀粉样物质的肿瘤可能涉及更深层的组织，并有更具侵袭性的行为。由于细胞数量少和大量淀粉样物质的存在，这些肿瘤可能难以诊断。
