Duke University Medical Center, Durham, DUMC 3712, NC 27710, USA.
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, P.O. Box 100275, Gainesville, FL 32610, USA.
Hematol Oncol Clin North Am. 2022 Feb;36(1):1-21. doi: 10.1016/j.hoc.2021.08.001. Epub 2021 Nov 4.
In 2016, the World Health Organization Classification of CNS Tumors introduced molecular abnormalities that refined tumor diagnoses. Around this time, the introduction of large scale genetic mutational analyses quickly advanced our knowledge of recurrent abnormalities in disease. In 2017, the C-IMPACT group was established to render expert consensus opinions regarding the application of molecular findings into central nervous system tumor diagnoses. C-IMPACT have presented their recommendations in 7 peer-reviewed publications; this article details those recommendations that are expected to be incorporated into the upcoming fifth edition of the World Health Organization classification.
2016 年，世界卫生组织中枢神经系统肿瘤分类引入了分子异常，从而完善了肿瘤诊断。大约在这个时候，大规模基因突变分析的引入迅速提高了我们对疾病中复发性异常的认识。2017 年，C-IMPACT 小组成立，旨在就分子发现应用于中枢神经系统肿瘤诊断提出专家共识意见。C-IMPACT 在 7 篇同行评议出版物中提出了他们的建议；本文详细介绍了预计将纳入即将发布的第五版世界卫生组织分类的建议。
