Department of Pulmonology, Centre Hospitalier d'Abbeville, Abbeville, France.
Department of Pulmonology, CHU Amiens, Amiens, France.
Clin Lung Cancer. 2022 Jan;23(1):e54-e59. doi: 10.1016/j.cllc.2021.09.009. Epub 2021 Oct 10.
Over the last few years, lung cancer screening by low-dose CT scan has demonstrated a decrease in lung cancer mortality. While this method has been in use since 2013 in the United States of America, no European country has yet implemented a systematic screening program. We hereby report the results from the second round of screening from a French cohort study.
DEP KP80 is a prospective study evaluating lung cancer screening by means of three low-dose computer tomography (CT) scans at 1-year intervals in 1,307 participants, aged 55 to 74 years old, all smokers or former smokers, having quit within the last 15 years, with over 30 pack years. The results of the first round demonstrated it was possible to conduct effective screening in real-life situations.
Participation was lower in this second round than in the first (35.3% vs. 73.1%, P < .001). The rate of negative results was significantly higher and that of undetermined results lower than those produced in the first round. Overall, 75% of cancers revealed were Stage 1 and 87.5% benefitted from surgical treatment. The incidence of cancer in the second round was 2.43%.
As with the first round, the results of this second round confirm the feasibility and efficacy of lung cancer screening. The lower participation rate for this second round is proof of the need to improve awareness among participants and healthcare professionals of the relevance of committing to an annual screening program.
在过去的几年中，低剂量 CT 扫描肺癌筛查已经证明可以降低肺癌死亡率。虽然这种方法自 2013 年以来在美国就已使用，但没有欧洲国家实施过系统的筛查计划。在此，我们报告了法国队列研究第二轮筛查的结果。
DEP KP80 是一项前瞻性研究，评估了通过三低剂量计算机断层扫描（CT）扫描在 1307 名年龄在 55 至 74 岁之间的参与者中进行的肺癌筛查，所有参与者均为吸烟者或曾吸烟者，在过去 15 年内已戒烟，吸烟量超过 30 包年。第一轮的结果表明，在现实生活中可以有效地进行筛查。
第二轮的参与率低于第一轮（35.3%对 73.1%，P <.001）。阴性结果的比例明显更高，不确定结果的比例低于第一轮。总体而言，75%的癌症为 1 期，87.5%受益于手术治疗。第二轮的癌症发病率为 2.43%。
与第一轮一样，第二轮的结果证实了肺癌筛查的可行性和有效性。第二轮的参与率较低证明需要提高参与者和医疗保健专业人员对承诺参加年度筛查计划的相关性的认识。
