Department of Chest Diseases, Faculty of Medicine, Afyonkarahisar Health Sciences University, Chest Diseases Clinic, Block C Floor: 5, Izmir Highway 3 km, 03200, Afyonkarahisar, Turkey.
Department of Endocrinology and Metabolism, Afyonkarahisar Health Science University, Afyonkarahisar, Turkey.
Sci Rep. 2021 Nov 11;11(1):22058. doi: 10.1038/s41598-021-01553-3.
Hypoxia is linked to an inflammatory imbalance in obstructive sleep apnea syndrome (OSAS). Circulating soluble tumor necrosis factor (TNF)-like weak inducer of apoptosis (sTWEAK) is a cytokine that regulates inflammation and insulin resistance in adipose tissue. This study first investigated sTWEAK concentrations in patients OSAS and evaluated associations between sTWEAK concentrations and visceral adiposity, metabolic dysfunction, and hypoxia observed in OSAS. Forty age, sex, and body mass index-matched patients with simple habitual snoring (HSS) and 70 patients with OSAS were included. Patients were divided according to OSAS severity: mild-moderate (apnea-hypopnea index, AHI 5-30 events/h) and severe (AHI ≥ 30 events/h). Anthropometric data, glucose metabolism, visceral fat (VF) ratio, and sTWEAK levels were compared. sTWEAK levels were higher in the OSAS group than in the HSS group (931.23 ± 136.48 vs. 735.22 ± 102.84 ng/L, p = 0.001). sTWEAK levels were higher in severe OSAS than in mild-moderate OSAS (1031.83 ± 146.69 vs. 891.01 ± 110.01 ng/L, p = 0.002. When we evaluated the sTWEAK value and AHI, VF ratio, total cholesterol, blood pressure, homeostasis model of assessment-insulin resistance, and high-sensitivity C-reactive protein using multiple regression analysis, a significant correlation was found between sTWEAK levels and AHI (p < 0.001). It was found that sTWEAK levels were not correlated with glucose metabolism and VF ratio. Increased circulating sTWEAK levels were associated with the severity of OSAS. High sTWEAK levels were correlated with increased AHI. sTWEAK concentrations are linked to severe OSAS.
缺氧与阻塞性睡眠呼吸暂停综合征（OSAS）中的炎症失衡有关。循环可溶性肿瘤坏死因子（TNF）样凋亡弱诱导剂（sTWEAK）是一种细胞因子，可调节脂肪组织中的炎症和胰岛素抵抗。本研究首先调查了 OSAS 患者的 sTWEAK 浓度，并评估了 sTWEAK 浓度与 OSAS 中观察到的内脏肥胖、代谢功能障碍和缺氧之间的关系。纳入了 40 名年龄、性别和体重指数匹配的单纯习惯性打鼾（HSS）患者和 70 名 OSAS 患者。根据 OSAS 严重程度将患者分为轻度-中度（呼吸暂停-低通气指数，AHI 5-30 事件/小时）和重度（AHI≥30 事件/小时）。比较了人体测量数据、葡萄糖代谢、内脏脂肪（VF）比和 sTWEAK 水平。OSAS 组的 sTWEAK 水平高于 HSS 组（931.23±136.48 vs. 735.22±102.84ng/L，p=0.001）。重度 OSAS 组的 sTWEAK 水平高于轻度-中度 OSAS 组（1031.83±146.69 vs. 891.01±110.01ng/L，p=0.002）。当我们使用多元回归分析评估 sTWEAK 值与 AHI、VF 比、总胆固醇、血压、胰岛素抵抗评估的稳态模型、高敏 C 反应蛋白时，发现 sTWEAK 水平与 AHI 之间存在显著相关性（p<0.001）。结果发现，sTWEAK 水平与葡萄糖代谢和 VF 比无关。循环 sTWEAK 水平升高与 OSAS 的严重程度有关。高 sTWEAK 水平与 AHI 增加相关。sTWEAK 浓度与严重 OSAS 有关。
