Golubickaite Ieva, Ugenskiene Rasa, Cepaite Juste, Ziliene Egle, Inciura Arturas, Poskiene Lina, Juozaityte Elona
Department of Genetics and Molecular Medicine, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Institute of Oncology, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Biomed Rep. 2021 Dec;15(6):106. doi: 10.3892/br.2021.1482. Epub 2021 Oct 28.
Cervical cancer is the fourth most common type of cancer in women worldwide, with high incidence and mortality rates, particularly in developing countries. There are human papillomavirus vaccines and cytological screening programs available; however, there are no molecular markers that would aid the prognosis of the course of the disease or prediction of the outcomes of the patients. The aim of the present study was to investigate the associations between single nucleotide polymorphisms (SNPs) of the mitochondrial transcription factor A () gene (rs11006132, rs11006129, rs1937, rs16912174, rs16912202 and rs3900887), and the clinical parameters and tumor phenotype of patients with cervical cancer. DNA isolated from patients with cervical cancer (n=172) was used for genotyping using Real-Time PCR using TaqMan probes. It was revealed that the rs3900887 TT and AT genotypes were associated with a lower risk of developing larger tumors. The results showed an association between the rs3900887 SNP and tumor phenotype, indicating rs3900887 as a potential biomarker for tumor size in cervical cancer.
宫颈癌是全球女性中第四大常见癌症类型，发病率和死亡率都很高，在发展中国家尤为如此。目前有人类乳头瘤病毒疫苗和细胞学筛查项目；然而，尚无有助于疾病进程预后或患者预后预测的分子标志物。本研究的目的是调查线粒体转录因子A（）基因的单核苷酸多态性（SNP）（rs11006132、rs11006129、rs1937、rs16912174、rs16912202和rs3900887）与宫颈癌患者临床参数和肿瘤表型之间的关联。从宫颈癌患者（n = 172）中分离的DNA用于使用TaqMan探针的实时PCR进行基因分型。结果显示，rs3900887的TT和AT基因型与发生较大肿瘤的风险较低相关。结果表明rs3900887 SNP与肿瘤表型之间存在关联，表明rs3900887是宫颈癌肿瘤大小的潜在生物标志物。
