Voicu Mirela Nicoleta, Ahmet Ana Maria, Turcu-Stiolica Adina, Ungureanu Bogdan Silviu, Dragoescu Alice Nicoleta, Popescu Florica
Phd Student, Department of Pharmacology, University of Medicine and Pharmacy of Craiova, Romania.
Student, University of Medicine and Pharmacy of Craiova, Romania.
Curr Health Sci J. 2021 Apr-Jun;47(2):204-208. doi: 10.12865/CHSJ.47.02.09. Epub 2021 Jun 30.
infection (CDI) is the leading cause of antibiotic related diarrhea therapy and may associate high morbidity and mortality. Providing a potential biomarker to assess disease severity may help physicians in choosing the right treatment.
This was a prospective, single-centre cohort study which included patients diagnosed with CDI which were assessed by fecal calprotectin (FC).
Patients included had a mean of 69.29 years of age, 54.23% of male gender. Patients diagnosed with mild CDI had a mean ATLAS score of 3.39 (±1.24), statistically lower (p<0.001) than patients with severe CDI who had a mean ATLAS score of 7.33 (±0.77). Fecal calprotectin concentrations were significantly higher (p<0.001) in the severe CDI patients (615.14μg/g; IQR, 403.62-784.4μg/g) than in the mild CDI patients (195.42μg/g; IQR, 131.12-298.59μg/g). We suggest a cut-off of 290.09μg/g for the predictive marker of fecal calprotectin, which permitted to identify patients with severe and mild CDI, having 100% sensitivity and 76% specificity.
Our findings point out the potential that FC might have, as a biomarker for disease severity. However, future multicentre studies and in larger cohort need to validate the results.
艰难梭菌感染（CDI）是抗生素相关性腹泻治疗的主要原因，可能伴有高发病率和死亡率。提供一种潜在的生物标志物来评估疾病严重程度可能有助于医生选择正确的治疗方法。
这是一项前瞻性、单中心队列研究，纳入了经粪便钙卫蛋白（FC）评估诊断为CDI的患者。
纳入患者的平均年龄为69.29岁，男性占54.23%。诊断为轻度CDI的患者平均ATLAS评分为3.39（±1.24），在统计学上低于重度CDI患者（平均ATLAS评分为7.33（±0.77），p<0.001）。重度CDI患者的粪便钙卫蛋白浓度（615.14μg/g；四分位间距，403.62 - 784.4μg/g）显著高于轻度CDI患者（195.42μg/g；四分位间距，131.12 - 298.59μg/g，p<0.001）。我们建议将粪便钙卫蛋白预测标志物的临界值设定为290.09μg/g，这能够识别重度和轻度CDI患者，灵敏度为100%，特异性为76%。
我们的研究结果指出了FC作为疾病严重程度生物标志物的潜在可能性。然而，未来需要多中心研究以及更大规模的队列来验证这些结果。
