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与浅表性黑色素瘤相比，结节性黑色素瘤病例发病率增加的临床研究。

Clinical Study on the Increased Incidence of Nodular Melanoma Cases Compared to Superficial Melanoma.

作者信息

Anghel-Savciu Rumi-Eugen, Rădulescu Cicerone, Dobre Cristiana, Ciurea Marius Eugen, Ciurea Ana Maria, Anghel-Savciu Nicoleta-Loredana, Vrabete Maria

机构信息

PhD Student, Doctoral School, University of Medicine and Pharmacy of Craiova, Romania.

Department of Plastic Surgery and Reconstructive Microsurgery, Emergency County Hospital, Craiova, Romania.

出版信息

Curr Health Sci J. 2021 Apr-Jun;47(2):298-305. doi: 10.12865/CHSJ.47.02.22. Epub 2021 Jun 30.

DOI:10.12865/CHSJ.47.02.22
PMID:34765252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8551895/
Abstract

Our study group was comprised of 67 patients with melanoma, admitted and operated in our clinic between 2010-2018. Only the patients with melanoma localized on the head, torso and upper limb were selected for our study. We attempted to establish a link between the clinical appearance, presence or absence of ulceration, presence or absence of regional lymphadenopathy or distant metastases, surgical technique, histopathological type, Clark level and Breslow depth, disease stage (TNM), adjuvant therapies and survival rates at 1, 3, 5 and 10 years.

摘要

我们的研究组由67例黑色素瘤患者组成，这些患者于2010年至2018年间在我们诊所入院并接受手术。仅选择头部、躯干和上肢出现黑色素瘤的患者纳入我们的研究。我们试图建立临床外观、溃疡的有无、区域淋巴结病或远处转移的有无、手术技术、组织病理学类型、克拉克分级和布雷斯洛厚度、疾病分期（TNM）、辅助治疗与1年、3年、5年和10年生存率之间的联系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/28826be2a11a/CHSJ-47-02-298-fig16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/5df1f114abee/CHSJ-47-02-298-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/992fd014d137/CHSJ-47-02-298-fig2.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/2e1bac573d92/CHSJ-47-02-298-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/72a3f6c27a19/CHSJ-47-02-298-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/9eca15683b51/CHSJ-47-02-298-fig6.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/b1f9b558a875/CHSJ-47-02-298-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/84f910a3e955/CHSJ-47-02-298-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/942bf5259447/CHSJ-47-02-298-fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/4079074d94e1/CHSJ-47-02-298-fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/d6b61c8a7d2b/CHSJ-47-02-298-fig12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/e3b38a40c00d/CHSJ-47-02-298-fig13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/72221fd48bd3/CHSJ-47-02-298-fig14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/2d6f2cbd74c1/CHSJ-47-02-298-fig15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/28826be2a11a/CHSJ-47-02-298-fig16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/5df1f114abee/CHSJ-47-02-298-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/992fd014d137/CHSJ-47-02-298-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/1d7aba652892/CHSJ-47-02-298-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/2e1bac573d92/CHSJ-47-02-298-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/72a3f6c27a19/CHSJ-47-02-298-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/9eca15683b51/CHSJ-47-02-298-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/608771cb9a31/CHSJ-47-02-298-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/b1f9b558a875/CHSJ-47-02-298-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/84f910a3e955/CHSJ-47-02-298-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/942bf5259447/CHSJ-47-02-298-fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/4079074d94e1/CHSJ-47-02-298-fig11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/d6b61c8a7d2b/CHSJ-47-02-298-fig12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/e3b38a40c00d/CHSJ-47-02-298-fig13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/72221fd48bd3/CHSJ-47-02-298-fig14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/2d6f2cbd74c1/CHSJ-47-02-298-fig15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388f/8551895/28826be2a11a/CHSJ-47-02-298-fig16.jpg

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The contribution of nodular subtype to melanoma mortality in the United States, 1978 to 2007.1978年至2007年美国结节状亚型对黑色素瘤死亡率的影响。
Arch Dermatol. 2012 Jan;148(1):30-6. doi: 10.1001/archdermatol.2011.264. Epub 2011 Sep 19.
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Quantitative visualization and detection of skin cancer using dynamic thermal imaging.使用动态热成像对皮肤癌进行定量可视化和检测。
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Integrative genomics identifies molecular alterations that challenge the linear model of melanoma progression.整合基因组学鉴定出了挑战黑色素瘤进展线性模型的分子改变。
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Nestin is expressed in HMB-45 negative melanoma cells in dermal parts of nodular melanoma.巢蛋白在结节性黑色素瘤皮肤部分的 HMB-45 阴性黑色素瘤细胞中表达。
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