Alipour Fateme, Ansari Shabnam, Dadman Nima, Hafezi Farhad
Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Department of Ophthalmology, Geneva University Hospitals, Geneva, Switzerland.
J Curr Ophthalmol. 2021 Oct 22;33(3):285-290. doi: 10.4103/joco.joco_163_20. eCollection 2021 Jul-Sep.
To evaluate the visual, refractive, and topographic outcomes of accelerated corneal collagen cross-linking (CXL) in the pediatric age group.
In this retrospective case series study, 89 eyes of 56 patients with progressive keratoconus (KCN) who were under or equal to 18 years old at the time of surgery were included. All patients underwent accelerated corneal CXL. A thorough baseline and follow-up ophthalmic examination including uncorrected distance visual acuity, best corrected visual acuity (BCVA), slit-lamp and fundus examination, and corneal tomography by Scheimpflg camera Pentacam (Oculus, Wetzlar, Germany) were performed.
The mean age of patients was 16.2 ± 1.8 years. Mean follow-up was 16.46 ± 11.6 months (range, 6-40 months). The mean BCVA improved significantly from 0.26 ± 0.26 to 0.16 ± 0.19 (logMAR) after accelerated CXL ( < 0.001). The mean corneal astigmatism based on refraction decreased from 3.69 ± 2.12 to 3.15 ± 1.86 after the intervention ( = 0.016). The mean maximum keratometry (K) reduced significantly from 53.23 ± 6.07 diopter (D) to 52.23 ± 6.33 D ( = 0.047). The mean flat keratometry (K) reduced from 46.37 ± 3.69 to 45.95 ± 3.65 after the intervention ( = 0.119).
Our study shows that accelerated CXL increases visual acuity and stabilizes or improves keratometric indices in pediatric patients with progressive KCN without any serious complication for a mean follow-up time of 16 months.
评估儿童年龄组中加速角膜胶原交联（CXL）的视觉、屈光和地形图结果。
在这项回顾性病例系列研究中，纳入了56例手术时年龄小于或等于18岁的进行性圆锥角膜（KCN）患者的89只眼。所有患者均接受了加速角膜CXL。进行了全面的基线和随访眼科检查，包括未矫正远视力、最佳矫正视力（BCVA）、裂隙灯和眼底检查，以及使用Scheimpflg相机Pentacam（德国韦茨拉尔奥culus公司）进行角膜断层扫描。
患者的平均年龄为16.2±1.8岁。平均随访时间为16.46±11.6个月（范围6 - 40个月）。加速CXL后，平均BCVA从0.26±0.26显著提高到0.16±0.19（logMAR）（P<0.001）。干预后，基于验光的平均角膜散光从3.69±2.12降至3.15±1.86（P = 0.016）。平均最大角膜曲率（K）从53.23±6.07屈光度（D）显著降低至52.23±6.33 D（P = 0.
