Department of Periodontology, School of Dental Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Microbiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Ir J Med Sci. 2022 Oct;191(5):2207-2211. doi: 10.1007/s11845-021-02850-6. Epub 2021 Nov 12.
Surgical site infection (SSI) is a possible postoperative complication. Preoperative application of antiseptics on the surgical site can decrease the rate of SSIs.
This study aimed to compare the efficacy of 0.2% chlorhexidine (CHX) and 10% Betadine (povidone-iodine) for perioral skin disinfection prior to oral surgical procedures.
This clinical trial (IRCT20181017041365N1) (registration date: 2019/05/04) evaluated 57 male patients who were randomly selected among those presenting to the Periodontology Department of Ahvaz Jundishapur University. Baseline microbial samples were collected from the perioral skin at the right and left sides of the face in each patient by sterile swabs. Next, the perioral area was disinfected with 10% Betadine in the right side and 0.2% CHX in the left side. Secondary microbial samples were then collected. Wilcoxon matched-pairs signed-ranks and Mann-Whitney test were used to compare the colony counts. The significance level was set at p ≤ 0.05. Data were analyzed with the Stata program, version15.1.
The bacterial colony count was 3147 (314,700) in the Betadine and 3139 (313,900) in the CHX group at baseline (P = 0.86). These values changed to 1196 (119,600) in the Betadine (P < 0.001) and 857 (85,700) in the CHX (P < 0.001) group after disinfection. A significant difference was found in colony count between the CHX and Betadine groups after intervention (P = 0.0001).
According to the results, 0.2% CHX has higher antimicrobial efficacy than 10% Betadine for perioral disinfection prior to oral surgical procedures.
IRCT20181017041365N1. Registered on 2019/05/04.
手术部位感染（SSI）是一种可能的术后并发症。术前在手术部位使用防腐剂可以降低 SSI 的发生率。
本研究旨在比较 0.2%洗必泰（CHX）和 10%聚维酮碘（碘伏）在口腔手术前对口周皮肤消毒的效果。
本临床试验（IRCT20181017041365N1）（注册日期：2019 年 5 月 4 日）评估了 57 名随机选自阿瓦兹 Jundishapur 大学牙周病科的男性患者。每位患者的面部右侧和左侧口周皮肤均用无菌拭子采集基线微生物样本。然后，右侧用 10%碘伏，左侧用 0.2%CHX 对口周区域进行消毒。然后采集二次微生物样本。采用 Wilcoxon 配对符号秩和检验和 Mann-Whitney 检验比较菌落计数。显著性水平设为 p≤0.05。数据采用 Stata 程序（版本 15.1）进行分析。
碘伏组的细菌菌落计数为 3147（314700），CHX 组为 3139（313900），基线时（P=0.86）。碘伏组的菌落计数降至 1196（119600）（P<0.001），CHX 组降至 857（85700）（P<0.001）。干预后 CHX 组和碘伏组的菌落计数有显著差异（P=0.0001）。
根据结果，0.2%CHX 对口周消毒的抗菌效果优于 10%碘伏，适用于口腔手术前。
IRCT20181017041365N1。注册于 2019 年 5 月 4 日。
