非编码 RNA 在自闭症谱系障碍中的新兴作用。
Emerging Role of Non-coding RNAs in Autism Spectrum Disorder.
机构信息
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland.
出版信息
J Mol Neurosci. 2022 Feb;72(2):201-216. doi: 10.1007/s12031-021-01934-3. Epub 2021 Nov 12.
Autism spectrum disorders (ASD) embrace a diverse set of neurodevelopmental diseases with a multifaceted genetic basis. Non-coding RNAs (ncRNAs) are among putative loci with critical participation in the development of ASD. Expression of some lncRNAs, namely RP11-466P24.2, SYP-AS1, STXBP5-AS1, and IFNG-AS1 has been decreased in ASD, while AK128569, CTD-2516F10.2, MSNP1AS, RPS10P2-AS1, LINC00693, LINC00689, NEAT1, TUG1, and Shank2-AS lncRNAs have been over-expressed in ASD. Expression of several miRNAs which are implicated in the immunological developmental, immune responses, and protein synthesis as well as those participating in the regulation of PI3K/Akt/mTOR and EGFR signaling pathways is dysregulated in the context of ASD. In the present article, we describe investigations which appraised the role of lncRNAs, miRNAs, and circRNAs in the pathobiology of ASD.
自闭症谱系障碍（ASD）包含一组具有多种遗传基础的神经发育疾病。非编码 RNA（ncRNA）是潜在的关键参与 ASD 发生的位点之一。一些 lncRNA 的表达，如 RP11-466P24.2、SYP-AS1、STXBP5-AS1 和 IFNG-AS1，在 ASD 中减少，而 AK128569、CTD-2516F10.2、MSNP1AS、RPS10P2-AS1、LINC00693、LINC00689、NEAT1、TUG1 和 Shank2-AS lncRNA 在 ASD 中过度表达。一些 miRNA 的表达也失调，这些 miRNA 参与免疫发育、免疫反应和蛋白质合成，以及参与 PI3K/Akt/mTOR 和 EGFR 信号通路的调节。在本文中，我们描述了评估 lncRNA、miRNA 和 circRNA 在 ASD 病理生物学中的作用的研究。
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