Wright W E
J Periodontol. 1987 Aug;58(8):559-63. doi: 10.1902/jop.1987.58.8.559.
Radiation treatment to the head and neck and cytotoxic chemotherapy can produce deleterious side effects to the periodontium that are generally transient in nature, reversible, and do not result in permanently visible defects. However, combinations of the malignant disease itself, the direct and indirect effects of medical therapy and associated oral infections, along with local trauma can lead to periodontal tissue destruction with resulting permanent architectural defects. Five case reports illustrate destructive alterations of the periodontium that were associated with oncology therapy. Proposed guidelines for periodontal treatment of compromised individuals undergoing oncology therapies are suggested.
对头颈部进行放射治疗和细胞毒性化疗会对牙周组织产生有害的副作用，这些副作用通常是暂时的、可逆的，不会导致永久性的明显缺损。然而，恶性疾病本身、医学治疗的直接和间接影响、相关的口腔感染以及局部创伤等因素综合起来，可能会导致牙周组织破坏，从而产生永久性的结构缺损。五例病例报告说明了与肿瘤治疗相关的牙周组织破坏性改变。文中还提出了针对接受肿瘤治疗的身体状况不佳个体的牙周治疗指导原则。
