Key Laboratory of Synthetic and Nature Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University. Xi'an 710127, PR China.
School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, PR China.
Org Lett. 2021 Dec 3;23(23):9241-9245. doi: 10.1021/acs.orglett.1c03589. Epub 2021 Nov 12.
Rhodium-catalyzed asymmetric desymmetrization Pauson-Khand reaction of C4-alkynyl-tethered cyclohexadienones has been developed as a novel strategy for access to fused 6-5-5 tricycles bearing three consecutive stereogenic centers. An array of chiral tricyclo[6.2.1.0]undecenes have been synthesized in high yields and enantioselectivities in a single step under mild conditions. This strategy employs readily accessible internal-olefin-containing 1,6-enynes, providing a potentially powerful tool for constructing chiral polycyclic scaffolds of complex molecules containing cyclopentenones and cyclohexenones.
铑催化的 C4-炔基环戊二烯酮的不对称去对称 Pauson-Khand 反应已被开发为一种新策略，用于获得具有三个连续手性中心的稠合 6-5-5 三环[6.2.1.0]十一烷。在温和条件下，通过一步反应，以高产率和对映选择性合成了一系列手性三环[6.2.1.0]十一烯。该策略采用易得的含有内烯烃的 1,6-烯炔，为构建含有环戊烯酮和环己烯酮的复杂分子的手性多环支架提供了一种潜在的强大工具。
