Institute of Material Research and Engineering, A*STAR (Agency for Science, Technology and Research) Research Entities, 2 Fusionopolis Way, Innovis #08-03, Singapore 138634, Singapore.
Department of Materials Science and Engineering, National University of Singapore (NUS), 9 Engineering Drive 1, Singapore 117576, Singapore.
Anal Chem. 2021 Nov 23;93(46):15543-15549. doi: 10.1021/acs.analchem.1c03719. Epub 2021 Nov 12.
Iodide (I) is an essential micronutrient for thyroid function. Hence, rapid and portable sensing is important for I quantification in food and biological samples. Herein, we report the first example of a halogen bonding (XB) tripodal ionophore () which is selective for the I anion. NMR binding studies of and its H-triazole analog with I demonstrated the dominant influence of XB interactions between the ionophore and the I analyte. The phase boundary model was applied to formulate iodide-selective electrodes with the ionophore . The optimal electrode exhibited a near-Nernstian response of -51.9 mV per decade within a large dynamic range (10 to 10 M) and notably anti-Hofmeister selectivity for I over thiocyanate (SCN), enabling the determination of I in complex samples. This work establishes XB as a viable supramolecular interaction in the potentiometric sensing of anions.
碘（I）是甲状腺功能的必需微量元素。因此，快速、便携的传感对于食品和生物样品中 I 的定量检测非常重要。在此，我们报道了首例卤键（XB）三足体离子载体（），它对 I 阴离子具有选择性。和其 H-三唑类似物与 I 的 NMR 结合研究表明，XB 相互作用在离子载体和 I 分析物之间具有主导影响。相界模型被应用于用离子载体构建碘选择性电极。最佳电极在大动态范围内（10 到 10 M）表现出接近 Nernst 响应的-51.9 mV 每十年，并且对碘化物相对于硫氰酸根（SCN）具有显著的反 Hofmeister 选择性，从而能够在复杂样品中测定 I。这项工作确立了 XB 在阴离子的电位传感中是一种可行的超分子相互作用。
