新型呼吸频率监测仪在慢性阻塞性肺疾病患者 6 分钟步行试验中的有效性：一种包含可拉伸应变传感器的监测仪。

Validity of a novel respiratory rate monitor comprising stretchable strain sensors during a 6-min walking test in patients with chronic pulmonary obstructive disease.

机构信息

Graduate School of Health Sciences Kobe University, 7-10-2 Tomogaoka, Suma-ku, Kobe, 654-0142, Japan; Faculty of Nursing, Osaka Medical Pharmaceutical University, 7-6 Hatchonishi-machi, Takatsuki, Osaka, 569-0095, Japan.

Graduate School of System Informatics, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe, 657-8501, Japan.

出版信息

Respir Med. 2021 Dec;190:106675. doi: 10.1016/j.rmed.2021.106675. Epub 2021 Nov 2.

DOI:10.1016/j.rmed.2021.106675

PMID:34768076

Abstract

BACKGROUND

Breathing frequency is rarely measured during a field walking test since the current monitoring system using a face mask is cumbersome for older adults. For effective clinical application, we aimed to validate the new respiratory monitor using wearable strain sensors during a 6-min walk test (6MWT) in young adults and patients with chronic obstructive pulmonary disease (COPD).

METHODS

The study included young adults and patients with stable COPD voluntarily recruited from three hospitals. Breathing frequency during 6MWT were measured by the strain sensor and a nasal capnometer. Total breathing frequencies were measured by the capnometer. The Bland-Altman method was used to estimate the mean limit of agreement for breathing frequency.

RESULTS

A total of 23 young adults (age = 23.1 ± 3.7, mean ± SD) and 50 patients with COPD (age = 75.2 ± 7.2, %FEV1 = 59.1 ± 19.7) were analyzed. During the entire test period, the total breathing frequencies were measured based on an average of 252 ± 46 breaths, and the total breathing frequency was higher in patients with COPD than in young adults (mean difference = -3.349, p < 0.0013). The mean difference in breathing frequency between the strain sensors and capnometer was -0.28 (95%CI: 0.75 to 0.20), and the limit of agreement ranged from -4.1 to 3.6. The CI of the limit of agreement included the limit of equivalence (4 counts/min).

CONCLUSIONS

The novel respiratory monitor with wearable sensors achieved the target accuracy in both young adults and patients with COPD in the 6MWT.

摘要

背景

由于当前使用面罩的监测系统对于老年人来说繁琐，因此在现场步行测试中很少测量呼吸频率。为了实现有效的临床应用，我们旨在验证在年轻成年人和慢性阻塞性肺疾病（COPD）患者的 6 分钟步行测试（6MWT）中使用可穿戴应变传感器的新型呼吸监测器。

方法

这项研究纳入了自愿从三家医院招募的年轻成年人和稳定期 COPD 患者。使用应变传感器和鼻夹二氧化碳计测量 6MWT 期间的呼吸频率。通过夹式二氧化碳计测量总的呼吸频率。使用 Bland-Altman 方法估计呼吸频率的平均限差。

结果

共分析了 23 名年轻成年人（年龄 23.1 ± 3.7，平均值 ± 标准差）和 50 名 COPD 患者（年龄 75.2 ± 7.2，%FEV1 59.1 ± 19.7）。在整个测试期间，根据平均 252 ± 46 次呼吸测量总的呼吸频率，并且 COPD 患者的总呼吸频率高于年轻成年人（平均差异 = -3.349，p < 0.0013）。应变传感器和夹式二氧化碳计之间的呼吸频率平均差异为-0.28（95%CI：0.75 至 0.20），一致性界限范围为-4.1 至 3.6。一致性界限的置信区间包含等效界限（4 次/分钟）。