Impact of Prior Statin Use on Reperfusion Rate and Stroke Outcomes in Patients Receiving Endovascular Treatment.

BACKGROUND

We evaluated the impact of prior statin use on successful reperfusion and stroke outcomes after endovascular treatment (EVT).

METHOD

Using consecutive multicenter databases, we enrolled acute ischemic stroke patients receiving EVT between 2015 and 2021. Patients were classified into prior statin users and no prior statin users after a review of premorbid medications. The primary outcome measure was successful reperfusion defined as modified TICI grade 2b or 3 after EVT. Secondary outcome measures were early neurologic deterioration (END) and a 3-month modified Rankin Scale (mRS) score of 0 to 2.

RESULTS

Among 385 patients receiving EVT, 74 (19.2%) were prior statin users, who had a significantly higher successful reperfusion rate compared with no prior statin users (94.6% versus 78.8%, = 0.002). Successful reperfusion and END occurrence were improved according to statin intensity with a dose-response relationship. In multivariate analysis, prior statin was associated with successful reperfusion after EVT (adjusted odds ratio (95% confidence interval) 5.31 (1.67-16.86)). In addition, prior statin was associated with a lower occurrence of END and good functional status.

CONCLUSION

Our study showed that prior statin use before ischemic stroke might improve successful reperfusion and stroke outcomes after EVT.