多发性骨髓瘤中高剂量美法仑的口腔并发症。
Oral complications of high-dose melphalan in multiple myeloma.
作者信息
Barrett A P, Buckley D J
出版信息
Oral Surg Oral Med Oral Pathol. 1987 Aug;64(2):264-7. doi: 10.1016/0030-4220(87)90102-2.
PMID:3476906
Abstract
Four patients with multiple myeloma refractory to conventional chemotherapy received high-dose melphalan. All experienced multiple oral complications. Extensive neutropenic ulceration and orofacial herpes simplex virus infection caused considerable morbidity in three patients during prolonged periods of neutropenia.
摘要
4例对传统化疗难治的多发性骨髓瘤患者接受了大剂量美法仑治疗。所有患者均出现多种口腔并发症。在长期中性粒细胞减少期间，广泛的中性粒细胞减少性溃疡和口腔单纯疱疹病毒感染给3例患者带来了相当大的发病率。
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