非接触式常压低温等离子体处理的抗黑色素瘤能力。
Anti-Melanoma Capability of Contactless Cold Atmospheric Plasma Treatment.
机构信息
Department of Mechanical and Aerospace Engineering, George Washington University, Washington, DC 20052, USA.
School of Medicine and Health Science, George Washington University, Washington, DC 20052, USA.
出版信息
Int J Mol Sci. 2021 Oct 29;22(21):11728. doi: 10.3390/ijms222111728.
In this study, we demonstrated that the widely used cold atmospheric plasma (CAP) jet could significantly inhibit the growth of melanoma cells using a contactless treatment method, The flow rate of helium gas was a key operational parameter to modulate electromagnetic (EM) effect on melanoma cells. Metal sheets with different sizes could be used as a strategy to control the strength of EM effect. More attractive, the EM effect from CAP could penetrate glass/polystyrene barriers as thick as 7 mm. All these discoveries presented the profound non-invasive nature of a physically based CAP treatment, which provided a solid foundation for CAP-based cutaneous/subcutaneous tumor therapy.
在这项研究中，我们证明了广泛使用的冷等离体射流（CAP）可以通过非接触式处理方法显著抑制黑色素瘤细胞的生长。氦气流速是调节电磁（EM）对黑色素瘤细胞影响的关键操作参数。不同尺寸的金属片可用作控制 EM 效应强度的策略。更有吸引力的是，CAP 的 EM 效应可以穿透厚达 7 毫米的玻璃/聚苯乙烯屏障。所有这些发现都展示了基于物理的 CAP 处理的深刻的非侵入性，为基于 CAP 的皮肤/皮下肿瘤治疗提供了坚实的基础。
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