非接触式常压低温等离子体处理的抗黑色素瘤能力。

Department of Mechanical and Aerospace Engineering, George Washington University, Washington, DC 20052, USA.

School of Medicine and Health Science, George Washington University, Washington, DC 20052, USA.

Int J Mol Sci. 2021 Oct 29;22(21):11728. doi: 10.3390/ijms222111728.

In this study, we demonstrated that the widely used cold atmospheric plasma (CAP) jet could significantly inhibit the growth of melanoma cells using a contactless treatment method, The flow rate of helium gas was a key operational parameter to modulate electromagnetic (EM) effect on melanoma cells. Metal sheets with different sizes could be used as a strategy to control the strength of EM effect. More attractive, the EM effect from CAP could penetrate glass/polystyrene barriers as thick as 7 mm. All these discoveries presented the profound non-invasive nature of a physically based CAP treatment, which provided a solid foundation for CAP-based cutaneous/subcutaneous tumor therapy.

在这项研究中，我们证明了广泛使用的冷等离体射流（CAP）可以通过非接触式处理方法显著抑制黑色素瘤细胞的生长。氦气流速是调节电磁（EM）对黑色素瘤细胞影响的关键操作参数。不同尺寸的金属片可用作控制 EM 效应强度的策略。更有吸引力的是，CAP 的 EM 效应可以穿透厚达 7 毫米的玻璃/聚苯乙烯屏障。所有这些发现都展示了基于物理的 CAP 处理的深刻的非侵入性，为基于 CAP 的皮肤/皮下肿瘤治疗提供了坚实的基础。