mRNA 在多发性骨髓瘤生物学中的意义及其临床意义。
The Significance of mRNA in the Biology of Multiple Myeloma and Its Clinical Implications.
机构信息
Department of Hematology, Medical University of Lodz, 93-510 Lodz, Poland.
Department of Experimental Hematology, Medical University of Lodz, 93-510 Lodz, Poland.
出版信息
Int J Mol Sci. 2021 Nov 8;22(21):12070. doi: 10.3390/ijms222112070.
Multiple myeloma (MM) is a genetically complex disease that results from a multistep transformation of normal to malignant plasma cells in the bone marrow. However, the molecular mechanisms responsible for the initiation and heterogeneous evolution of MM remain largely unknown. A fundamental step needed to understand the oncogenesis of MM and its response to therapy is the identification of driver mutations. The introduction of gene expression profiling (GEP) in MM is an important step in elucidating the molecular heterogeneity of MM and its clinical relevance. Since some mutations in myeloma occur in non-coding regions, studies based on the analysis of mRNA provide more comprehensive information on the oncogenic pathways and mechanisms relevant to MM biology. In this review, we discuss the role of gene expression profiling in understanding the biology of multiple myeloma together with the clinical manifestation of the disease, as well as its impact on treatment decisions and future directions.
多发性骨髓瘤（MM）是一种遗传复杂的疾病，源于骨髓中正常浆细胞向恶性浆细胞的多步转化。然而，导致 MM 起始和异质性演变的分子机制在很大程度上仍不清楚。要理解 MM 的致癌作用及其对治疗的反应，一个基本步骤是确定驱动突变。MM 中基因表达谱（GEP）的引入是阐明 MM 的分子异质性及其临床相关性的重要步骤。由于骨髓瘤中的一些突变发生在非编码区域，因此基于 mRNA 分析的研究为 MM 生物学相关的致癌途径和机制提供了更全面的信息。在这篇综述中，我们讨论了基因表达谱在理解多发性骨髓瘤生物学以及该疾病临床表现方面的作用，以及它对治疗决策和未来方向的影响。
Zotero 插件