School of International Pharmaceutical Business, China Pharmaceutical University, No. 639 Longmian Street, Nanjing 211198, China.
Center for Pharmacoeconomics and Outcomes Research, China Pharmaceutical University, No. 639 Longmian Street, Nanjing 211198, China.
Int J Environ Res Public Health. 2021 Oct 28;18(21):11360. doi: 10.3390/ijerph182111360.
Historically, studies suggested that intraoperative hypothermia (IH) could result in significant resource consumption, but more recent studies have found the opposite. The purpose of this study is to estimate the value of active warming devices for IH prevention based on synthesized evidence.
A cost-benefit analysis was conducted using the effect of active warming versus passive warming devices for intraoperative hypothermia from a meta-analysis. The item-based aggregated treatment cost approach was adopted to estimate the cost of each adverse event, which was then weighted to calculate the total cost of IH.
IH was associated with higher risks of bleeding, surgical site infection, and shivering compared with normothermia. The cost of one case of IH was $363.80, and the use of active warming devices might save $152.80. Extra investment in active warming (e.g., $291.00) might only be cost-beneficial when the minimum willingness-to-pay is $150.00.
Synthesized evidence showed that the cost of IH might be overestimated. Furthermore, the value of using active warming devices remains uncertain because the willingness to pay may vary between decision-makers. As not enough awareness of hypothermia prevention in some countries, further research into the clinical use of active warming devices during major surgeries is warranted.
历史上，有研究表明术中低体温（IH）可能导致大量资源消耗，但最近的研究发现情况正好相反。本研究旨在根据综合证据评估主动升温设备预防 IH 的价值。
采用荟萃分析中主动升温与被动升温设备对术中低体温的影响进行成本效益分析。采用基于项目的汇总治疗成本法估算每个不良事件的成本，然后加权计算 IH 的总成本。
与正常体温相比，IH 与出血、手术部位感染和寒战的风险增加有关。一例 IH 的成本为 363.80 美元，使用主动升温设备可能节省 152.80 美元。只有当最低支付意愿为 150.00 美元时，额外投资主动升温（例如，291.00 美元）才可能具有成本效益。
综合证据表明 IH 的成本可能被高估。此外，使用主动升温设备的价值仍不确定，因为决策者的支付意愿可能不同。由于一些国家对低体温预防的认识不足，有必要进一步研究主要手术中主动升温设备的临床应用。
