Bros Marie, Zaragori Timothée, Rech Fabien, Blonski Marie, Hossu Gabriela, Taillandier Luc, Marie Pierre-Yves, Verger Antoine
Department of Nuclear Medicine and Nancyclotep Imaging Platform, CHRU-Nancy, Université de Lorraine, F-54000 Nancy, France.
IADI UMR 1254, INSERM, Université de Lorraine, F-54000 Nancy, France.
Cancers (Basel). 2021 Oct 24;13(21):5340. doi: 10.3390/cancers13215340.
This study aimed to determine the impact of carbidopa premedication on static, dynamic and radiomics parameters of F-FDOPA PET in brain tumors.
The study included 54 patients, 18 of whom received carbidopa, who underwent F-FDOPA PET for newly diagnosed gliomas. SUV-derived, 105 radiomics features and TTP dynamic parameters were extracted from volumes of interest in healthy brains and tumors. Simulation of the effects of carbidopa on time-activity curves were generated.
All static and TTP dynamic parameters were significantly higher in healthy brain regions of premedicated patients (ΔSUV = +53%, ΔTTP = +48%, < 0.001). Furthermore, carbidopa impacted 81% of radiomics features, of which 92% correlated with SUV (absolute correlation coefficient ≥ 0.4). In tumors, premedication with carbidopa was an independent predictor of SUV (ΔSUV = +52%, < 0.001) and TTP (ΔTTP = +24%, = 0.025). All parameters were no longer significantly modified by carbidopa premedication when using ratios to healthy brain. Simulated data confirmed that carbidopa leads to higher tumor TTP values, corrected by the ratios.
In F-FDOPA PET, carbidopa induces similarly higher SUV and TTP dynamic parameters and similarly impacts SUV-dependent radiomics in healthy brain and tumor regions, which is compensated for by correcting for the tumor-to-healthy-brain ratio. This is a significant advantage for multicentric study harmonization.
本研究旨在确定卡比多巴预处理对脑肿瘤中F-FDOPA PET的静态、动态和放射组学参数的影响。
该研究纳入了54例患者，其中18例接受了卡比多巴治疗，这些患者因新诊断的胶质瘤接受了F-FDOPA PET检查。从健康脑区和肿瘤的感兴趣区提取SUV衍生参数、105个放射组学特征和TTP动态参数。生成了卡比多巴对时间-活性曲线影响的模拟结果。
预处理患者健康脑区的所有静态和TTP动态参数均显著更高（ΔSUV = +53%，ΔTTP = +48%，P < 0.001）。此外，卡比多巴影响了81%的放射组学特征，其中92%与SUV相关（绝对相关系数≥0.4）。在肿瘤中，卡比多巴预处理是SUV（ΔSUV = +52%，P < 0.001）和TTP（ΔTTP = +24%，P = 0.025）的独立预测因素。当使用与健康脑区的比值时，卡比多巴预处理对所有参数的影响不再显著。模拟数据证实，卡比多巴可使肿瘤TTP值升高，并通过比值进行校正。
在F-FDOPA PET中，卡比多巴在健康脑区和肿瘤区域诱导出类似的更高SUV和TTP动态参数，并对依赖SUV的放射组学产生类似影响，通过校正肿瘤与健康脑区的比值可对此进行补偿。这对多中心研究的标准化具有重要优势。
