Möschl P, Keiler A, Salem G, Szalay S, Glöckler M, Lubec G
Z Exp Chir. 1978;11(1):37-42.
This study is concerned with the significance of autoimmune processes caused by the damage of lung tissue after lungallo- and autotransplantation. In 15 mongrel dogs a left side lung-allotranplantation was performed, 5 of them were treated with immunsuppressive therapy in the posttransplantation period. A group of 5 dogs with autotransplantation of the left lung served as a control-group. In the posttransplantation period the development of humoral antibodies responding with lung basal membrane antigens was examined by daily taken sera as well as by elution of immuneglobulins from the rejected grafts in the passive hemagglutination and compared with the development of alloantibodies against donor-lung's tissue. Besides of regularly traceable humoral alloantibodies of lung allograft recipients in the posttransplantation period, in no group antilung basal membrane antibodies could be found.
本研究关注肺同种异体移植和自体移植后肺组织损伤引起的自身免疫过程的意义。对15只杂种犬进行了左侧肺同种异体移植，其中5只在移植后接受了免疫抑制治疗。一组5只接受左肺自体移植的犬作为对照组。在移植后期间，通过每日采集的血清以及从被动血凝反应中被排斥移植物洗脱免疫球蛋白来检测对肺基底膜抗原产生反应的体液抗体的发展，并与针对供体肺组织的同种异体抗体的发展进行比较。除了在移植后期间肺同种异体移植受者中可定期检测到的体液同种异体抗体外，在任何一组中均未发现抗肺基底膜抗体。
