与4号染色体上MNS血型相关的红发主要基因座。

Major locus for red hair color linked to MNS blood groups on chromosome 4.

作者信息

Eiberg H, Mohr J

机构信息

University Institute of Medical Genetics, Copenhagen, Denmark.

出版信息

Clin Genet. 1987 Aug;32(2):125-8. doi: 10.1111/j.1399-0004.1987.tb03339.x.

DOI:10.1111/j.1399-0004.1987.tb03339.x

PMID:3477350

Abstract

Red hair color (RHC) was studied in a Danish material of normal families that was tested earlier for 65 marker systems. We found 4.85% of the parents to be red-haired or to have been so early in life. Scoring RHC for linkage as an autosomal dominant against blond and as hypostatic to dark hair gave a lod score of z = 5.50 at theta = 0.05 in males and theta = 0.24 in females for the MNS blood group system; this assigns a major locus for red hair to chromosome 4.

摘要

在丹麦一个正常家庭的样本中对红头发色（RHC）进行了研究，该样本早前已针对65个标记系统进行过检测。我们发现4.85%的父母是红头发或早年曾是红头发。将RHC作为常染色体显性性状与金色头发进行连锁分析，并作为黑发的下位性状，对于MNS血型系统，在男性中θ = 0.05时连锁值（lod score）为z = 5.50，在女性中θ = 0.24时连锁值为z = 5.50；这将红头发的一个主要基因座定位到了4号染色体上。