RNA Biology Laboratory, Department of Chemistry, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016, India.
RNA Biology Laboratory, Department of Chemistry, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016, India; School of Interdisciplinary Research, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016, India.
Tuberculosis (Edinb). 2021 Dec;131:102142. doi: 10.1016/j.tube.2021.102142. Epub 2021 Nov 8.
Diverse mechanisms exist in Mycobacterium tuberculosis for adaptation to stresses leading to its persistence in the hostile environment of macrophages. Small RNA (sRNA)-mediated regulatory mechanisms have been scarcely explored in M. tuberculosis. MTS1338, a sRNA present only in pathogenic mycobacteria, was discovered to be highly abundant during infection and significantly contributes to host-pathogen interaction. A variety of stresses have been implicated for its accumulation. Herein, we showed that MTS1338 is an oxidative stress induced sRNA, which promotes the detoxification of reactive oxygen species (ROS) under oxidative stress. Current study identified a new role of MTS1338 in M. tuberculosis under oxidative stress.
分枝杆菌中有多种机制可使其适应压力，从而使其在巨噬细胞这种恶劣的环境中存活下来。在分枝杆菌中，很少有研究涉及到小 RNA（sRNA）介导的调控机制。MTS1338 是一种仅存在于致病性分枝杆菌中的 sRNA，研究发现它在感染过程中丰度很高，对宿主-病原体相互作用有重要贡献。多种应激因素与它的积累有关。本文中，我们发现 MTS1338 是一种氧化应激诱导的 sRNA，可促进氧化应激下活性氧（ROS）的解毒。本研究在氧化应激条件下确定了 MTS1338 在结核分枝杆菌中的一个新作用。
