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肾移植术后第三期甲状旁腺功能亢进症

Tertiary and Postrenal Transplantation Hyperparathyroidism.

作者信息

Alfieri Carlo, Mattinzoli Deborah, Messa Piergiorgio

机构信息

Department of Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca' Granda Ospedale Policlinico, Via Commenda 15, Milan 20122, Italy; Department of Clinical Sciences and Community Health, University of Milan, Via Festa del Perdono, 7, Milan 20122, Italy.

Renal Research Laboratory Fondazione IRCCS Ca' Granda Ospedale Policlinico, Via Pace 9, Milan 20122, Italy.

出版信息

Endocrinol Metab Clin North Am. 2021 Dec;50(4):649-662. doi: 10.1016/j.ecl.2021.08.004.

Abstract

Patients who have undergone kidney transplantation (KTx) (KTxps) are a distinctive population characterized by the persistence of some metabolic anomalies present during end-stage renal disease. Mineral metabolism (MM) parameters are frequently altered after KTx. These alterations involve calcium, phosphorus, vitamin D, and parathormone (PTH) disarrangements. At present, there is little consensus about the correct monitoring and management of PTH disorders in KTxps. This article presents the prevalence and epidemiologic and clinical impact of post-KTx hyper-PTH. The principal biochemical and instrumental investigations and the therapeutic options for these conditions are also reported.

摘要

接受过肾移植(KTx)的患者(KTx患者)是一个独特的群体,其特征是在终末期肾病期间存在的一些代谢异常持续存在。肾移植后矿物质代谢(MM)参数经常发生改变。这些改变涉及钙、磷、维生素D和甲状旁腺激素(PTH)紊乱。目前,关于KTx患者中PTH紊乱的正确监测和管理几乎没有共识。本文介绍了肾移植后高PTH的患病率、流行病学和临床影响。还报告了这些情况的主要生化和仪器检查以及治疗选择。

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