Department of Ophthalmology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Department of Ophthalmology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Early Hum Dev. 2021 Dec;163:105489. doi: 10.1016/j.earlhumdev.2021.105489. Epub 2021 Oct 16.
To examine whether smoking during pregnancy is correlated with long-term ophthalmic complications of the offspring.
A population-based cohort analysis was performed comparing all deliveries of mothers who reported smoking during pregnancy and non-smoking mothers between 1991 and 2014 at a single tertiary medical center. Hospitalizations of the offspring up to the age of 18 years involving ophthalmic morbidities were evaluated according to a predefined set of ICD-9 codes. A Kaplan-Meier curve was used to compare cumulative hospitalization rate in exposed and unexposed offspring and a Cox proportional hazards model was used to control for confounders.
During the study period, 243,680 deliveries met the inclusion criteria. Of them, 2965 (1.2%) were children of smoking mothers. Ophthalmic-related hospitalizations were significantly higher in children born to smoking mothers, as compared with the non-smoking group (1.4% vs. 0.1%, p < 0.01). Specifically, these hospitalizations were due to higher rates of visual disturbance rate and ophthalmic infections. The Kaplan-Meier curve demonstrated a significant higher cumulative incidence of ophthalmic-related hospitalizations in the smoking group (log rank p < 0.001). Using a Cox proportional hazards model, controlling for potential confounders, maternal tobacco use was found to be independently associated with long-term ophthalmic morbidity of the offspring (adjusted HR = 1.51, CI 1.11-2.04).
Maternal smoking during pregnancy is an independent risk factor for long-term ophthalmic morbidity of the offspring. These results are in line with many recent studies that strongly support maternal smoking cessation during pregnancy due to high offspring morbidity risk.
探讨孕期吸烟是否与后代长期眼部并发症有关。
这是一项基于人群的队列分析，比较了 1991 年至 2014 年在一家三级医疗中心报告孕期吸烟和不吸烟的所有母亲的分娩情况。根据预先设定的 ICD-9 编码，评估了 18 岁以下子女的眼科疾病住院情况。采用 Kaplan-Meier 曲线比较暴露组和未暴露组的累积住院率，采用 Cox 比例风险模型控制混杂因素。
在研究期间，符合纳入标准的分娩有 243680 例。其中，2965 例（1.2%）为吸烟母亲的子女。与不吸烟组相比，吸烟母亲的子女眼科相关住院率明显更高（1.4%比 0.1%，p<0.01）。具体而言，这些住院是由于视觉障碍和眼部感染的发生率较高。Kaplan-Meier 曲线显示吸烟组的眼科相关住院累积发生率显著更高（对数秩检验 p<0.001）。采用 Cox 比例风险模型，控制潜在混杂因素后，发现母亲吸烟与后代长期眼部发病率独立相关（调整后的 HR=1.51，95%CI 1.11-2.04）。
孕期吸烟母亲是后代长期眼部发病率的独立危险因素。这些结果与许多最近的研究一致，这些研究强烈支持由于高后代发病率风险，孕期应停止吸烟。
